CWC27 protein (Homo sapiens) - STRING network view

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CWC27

CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity) (472 aa)

Predicted Functional Partners:

SNW1

0.981

DHX38

0.977

SKIV2L2

0.974

CDC5L

0.961

PRPF19

0.958

XRCC4

0.905

PRKDC

0.896

BUD31

0.859

FRA10AC1

0.752

SIPA1L1

0.644

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BUD31	CDC5L	ENSP00000222969	ENSP00000360532	BUD31 homolog (S. cerevisiae)	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.978
BUD31	CWC27	ENSP00000222969	ENSP00000370460	BUD31 homolog (S. cerevisiae)	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	0.859
BUD31	DHX38	ENSP00000222969	ENSP00000268482	BUD31 homolog (S. cerevisiae)	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	0.628
BUD31	PRPF19	ENSP00000222969	ENSP00000227524	BUD31 homolog (S. cerevisiae)	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.980
BUD31	SNW1	ENSP00000222969	ENSP00000261531	BUD31 homolog (S. cerevisiae)	SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...]	0.962
CDC5L	BUD31	ENSP00000360532	ENSP00000222969	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	BUD31 homolog (S. cerevisiae)	0.978
CDC5L	CWC27	ENSP00000360532	ENSP00000370460	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	0.961
CDC5L	DHX38	ENSP00000360532	ENSP00000268482	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	0.790
CDC5L	PRKDC	ENSP00000360532	ENSP00000313420	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	protein kinase, DNA-activated, catalytic polypeptide	0.769
CDC5L	PRPF19	ENSP00000360532	ENSP00000227524	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.999
CDC5L	SNW1	ENSP00000360532	ENSP00000261531	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...]	0.991
CWC27	BUD31	ENSP00000370460	ENSP00000222969	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	BUD31 homolog (S. cerevisiae)	0.859
CWC27	CDC5L	ENSP00000370460	ENSP00000360532	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	CDC5 cell division cycle 5-like (S. pombe); DNA-binding protein involved in cell cycle control. May act as a transcription activator. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing	0.961
CWC27	DHX38	ENSP00000370460	ENSP00000268482	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	DEAH (Asp-Glu-Ala-His) box polypeptide 38; Probable ATP-binding RNA helicase involved in pre-mRNA splicing	0.977
CWC27	FRA10AC1	ENSP00000370460	ENSP00000360488	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.752
CWC27	PRKDC	ENSP00000370460	ENSP00000313420	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	protein kinase, DNA-activated, catalytic polypeptide	0.896
CWC27	PRPF19	ENSP00000370460	ENSP00000227524	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae); Plays a role in DNA double-strand break (DSB) repair. Binds double-stranded DNA in a sequence-nonspecific manner. Acts as a structural component of the nuclear framework. May also serve as a support for spliceosome binding and activity. Essential for spliceosome assembly in a oligomerization-dependent manner and might also be important for spliceosome stability. May have E3 ubiquitin ligase activity. The PSO4 complex is required in the DNA interstrand cross-links (ICLs) repair process. Component of the PRP19-CDC5L comple [...]	0.958
CWC27	SIPA1L1	ENSP00000370460	ENSP00000450832	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	signal-induced proliferation-associated 1 like 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F- actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)	0.644
CWC27	SKIV2L2	ENSP00000370460	ENSP00000230640	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	superkiller viralicidic activity 2-like 2 (S. cerevisiae); May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3’processing of the 7S pre-RNA to the mature 5.8S rRNA	0.974
CWC27	SNW1	ENSP00000370460	ENSP00000261531	CWC27 spliceosome-associated protein homolog (S. cerevisiae); PPIases accelerate the folding of proteins (By similarity)	SNW domain containing 1; Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators [...]	0.981

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