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STRINGSTRING
KRT7 KRT7 EWSR1 EWSR1 SLC4A3 SLC4A3 CD34 CD34 FLI1 FLI1 CD99 CD99 SHOX SHOX PRDM1 PRDM1 XG XG ARSH ARSH ARSF ARSF
CD99 molecule in Homo sapiens
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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CD99CD99 molecule; Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity) (185 aa)    
Predicted Functional Partners:
FLI1
Friend leukemia virus integration 1; Sequence-specific transcriptional activator. Recognizes the DNA sequence 5’-C[CA]GGAAGT-3’ (452 aa)
            score_image   0.941
CD34
CD34 molecule; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (385 aa)
            score_image   0.821
XG
Xg blood group (195 aa)
      score_image     score_image   0.818
EWSR1
Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes (661 aa)
            score_image   0.815
PRDM1
PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells (825 aa)
            score_image   0.800
SLC4A3
solute carrier family 4, anion exchanger, member 3; Plasma membrane anion exchange protein of wide distribution. Mediates at least a part of the Cl(-)/HCO3(-) exchange in cardiac myocytes. Both BAE3 and CAE3 forms transport Cl(-) (1259 aa)
            score_image   0.755
ARSF
arylsulfatase F (590 aa)
            score_image   0.744
ARSH
arylsulfatase family, member H (562 aa)
            score_image   0.742
SHOX
short stature homeobox; Controls fundamental aspects of growth and development (292 aa)
            score_image   0.730
KRT7
keratin 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7) (469 aa)
            score_image   0.700
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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