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STRINGSTRING
MOCS2 MOCS2 ENSG00000269099 ENSG00000269099 RCOR2 RCOR2 MAP3K1 MAP3K1 NIPBL NIPBL MIER3 MIER3 MRGBP MRGBP ZNF532 ZNF532 SETD9 SETD9 ZSWIM6 ZSWIM6 YPEL4 YPEL4
"MIER3" - mesoderm induction early response 1, family member 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MIER3mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) (549 aa)    
Predicted Functional Partners:
MRGBP
MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (204 aa)
        score_image       0.726
ZNF532
zinc finger protein 532; May be involved in transcriptional regulation (1301 aa)
            score_image   0.653
RCOR2
REST corepressor 2; May act as a component of a corepressor complex that represses transcription (Potential) (523 aa)
      score_image     score_image   0.599
ZSWIM6
zinc finger, SWIM-type containing 6 (1215 aa)
            score_image   0.591
MOCS2
molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (188 aa)
            score_image   0.553
SETD9
SET domain containing 9 (299 aa)
            score_image   0.535
YPEL4
yippee-like 4 (Drosophila) (127 aa)
            score_image   0.507
ENSG00000269099
Lymphocyte-specific protein 1 (45 aa)
            score_image   0.506
NIPBL
Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) (2804 aa)
            score_image   0.502
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (1512 aa)
            score_image   0.502
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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