node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000269099 | MAP3K1 | ENSP00000472039 | ENSP00000382423 | Lymphocyte-specific protein 1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.754 |
ENSG00000269099 | MIER3 | ENSP00000472039 | ENSP00000370611 | Lymphocyte-specific protein 1 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.506 |
MAP3K1 | ENSG00000269099 | ENSP00000382423 | ENSP00000472039 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | Lymphocyte-specific protein 1 | 0.754 |
MAP3K1 | MIER3 | ENSP00000382423 | ENSP00000370611 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.502 |
MIER3 | ENSG00000269099 | ENSP00000370611 | ENSP00000472039 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | Lymphocyte-specific protein 1 | 0.506 |
MIER3 | MAP3K1 | ENSP00000370611 | ENSP00000382423 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway | 0.502 |
MIER3 | MOCS2 | ENSP00000370611 | ENSP00000380157 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group | 0.553 |
MIER3 | MRGBP | ENSP00000370611 | ENSP00000359518 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | 0.726 |
MIER3 | NIPBL | ENSP00000370611 | ENSP00000282516 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | 0.502 |
MIER3 | RCOR2 | ENSP00000370611 | ENSP00000301459 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | REST corepressor 2; May act as a component of a corepressor complex that represses transcription (Potential) | 0.599 |
MIER3 | SETD9 | ENSP00000370611 | ENSP00000285947 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | SET domain containing 9 | 0.535 |
MIER3 | YPEL4 | ENSP00000370611 | ENSP00000300022 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | yippee-like 4 (Drosophila) | 0.507 |
MIER3 | ZNF532 | ENSP00000370611 | ENSP00000338217 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | zinc finger protein 532; May be involved in transcriptional regulation | 0.653 |
MIER3 | ZSWIM6 | ENSP00000370611 | ENSP00000252744 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | zinc finger, SWIM-type containing 6 | 0.591 |
MOCS2 | MIER3 | ENSP00000380157 | ENSP00000370611 | molybdenum cofactor synthesis 2; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.553 |
MRGBP | MIER3 | ENSP00000359518 | ENSP00000370611 | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.726 |
NIPBL | MIER3 | ENSP00000282516 | ENSP00000370611 | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.502 |
NIPBL | ZNF532 | ENSP00000282516 | ENSP00000338217 | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | zinc finger protein 532; May be involved in transcriptional regulation | 0.484 |
RCOR2 | MIER3 | ENSP00000301459 | ENSP00000370611 | REST corepressor 2; May act as a component of a corepressor complex that represses transcription (Potential) | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.599 |
SETD9 | MIER3 | ENSP00000285947 | ENSP00000370611 | SET domain containing 9 | mesoderm induction early response 1, family member 3; Transcriptional repressor (By similarity) | 0.535 |