GLDC protein (Homo sapiens) - STRING network view

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GLDC

glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (1020 aa)

Predicted Functional Partners:

AMT

0.999

SARDH

0.999

GCSH

0.999

DMGDH

0.997

SHMT1

0.996

SHMT2

0.995

PDPR

0.995

DLD

0.992

AGXT

0.965

AGXT2

0.953

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	AGXT2	ENSP00000302620	ENSP00000231420	alanine-glyoxylate aminotransferase	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	0.988
AGXT	DMGDH	ENSP00000302620	ENSP00000255189	alanine-glyoxylate aminotransferase	dimethylglycine dehydrogenase	0.415
AGXT	GCSH	ENSP00000302620	ENSP00000319531	alanine-glyoxylate aminotransferase	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.913
AGXT	GLDC	ENSP00000302620	ENSP00000370737	alanine-glyoxylate aminotransferase	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.965
AGXT	SARDH	ENSP00000302620	ENSP00000360938	alanine-glyoxylate aminotransferase	sarcosine dehydrogenase	0.929
AGXT	SHMT1	ENSP00000302620	ENSP00000318868	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.963
AGXT	SHMT2	ENSP00000302620	ENSP00000333667	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.961
AGXT2	AGXT	ENSP00000231420	ENSP00000302620	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	alanine-glyoxylate aminotransferase	0.988
AGXT2	GLDC	ENSP00000231420	ENSP00000370737	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.953
AGXT2	SARDH	ENSP00000231420	ENSP00000360938	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	sarcosine dehydrogenase	0.909
AGXT2	SHMT1	ENSP00000231420	ENSP00000318868	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.900
AGXT2	SHMT2	ENSP00000231420	ENSP00000333667	alanine--glyoxylate aminotransferase 2; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.913
AMT	DLD	ENSP00000273588	ENSP00000205402	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	0.990
AMT	GCSH	ENSP00000273588	ENSP00000319531	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.999
AMT	GLDC	ENSP00000273588	ENSP00000370737	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.999
AMT	SHMT1	ENSP00000273588	ENSP00000318868	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.985
AMT	SHMT2	ENSP00000273588	ENSP00000333667	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.988
DLD	AMT	ENSP00000205402	ENSP00000273588	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine (By similarity)	0.990
DLD	DMGDH	ENSP00000205402	ENSP00000255189	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	dimethylglycine dehydrogenase	0.493
DLD	GCSH	ENSP00000205402	ENSP00000319531	dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes. Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction	glycine cleavage system protein H (aminomethyl carrier); The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	0.901

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