node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GPR101 | GPR12 | ENSP00000298110 | ENSP00000370844 | G protein-coupled receptor 101; Orphan receptor | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | 0.423 |
GPR101 | GPR26 | ENSP00000298110 | ENSP00000284674 | G protein-coupled receptor 101; Orphan receptor | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | 0.760 |
GPR101 | GPR34 | ENSP00000298110 | ENSP00000367378 | G protein-coupled receptor 101; Orphan receptor | G protein-coupled receptor 34; Orphan receptor | 0.475 |
GPR12 | GPR101 | ENSP00000370844 | ENSP00000298110 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 101; Orphan receptor | 0.423 |
GPR12 | GPR26 | ENSP00000370844 | ENSP00000284674 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | 0.508 |
GPR12 | GPR34 | ENSP00000370844 | ENSP00000367378 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 34; Orphan receptor | 0.456 |
GPR12 | GPR4 | ENSP00000370844 | ENSP00000319744 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | 0.589 |
GPR12 | GPR61 | ENSP00000370844 | ENSP00000385422 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 61; Orphan receptor | 0.586 |
GPR12 | GPR87 | ENSP00000370844 | ENSP00000260843 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | G protein-coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage | 0.607 |
GPR12 | NPBWR2 | ENSP00000370844 | ENSP00000358783 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | neuropeptides B/W receptor 2; Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals | 0.470 |
GPR12 | NPPC | ENSP00000370844 | ENSP00000295440 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | natriuretic peptide C; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity) | 0.584 |
GPR12 | OXER1 | ENSP00000370844 | ENSP00000367930 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | oxoeicosanoid (OXE) receptor 1; Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins | 0.504 |
GPR12 | PDE3A | ENSP00000370844 | ENSP00000351957 | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | phosphodiesterase 3A, cGMP-inhibited; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity) | 0.532 |
GPR26 | GPR101 | ENSP00000284674 | ENSP00000298110 | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | G protein-coupled receptor 101; Orphan receptor | 0.760 |
GPR26 | GPR12 | ENSP00000284674 | ENSP00000370844 | G protein-coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | 0.508 |
GPR34 | GPR101 | ENSP00000367378 | ENSP00000298110 | G protein-coupled receptor 34; Orphan receptor | G protein-coupled receptor 101; Orphan receptor | 0.475 |
GPR34 | GPR12 | ENSP00000367378 | ENSP00000370844 | G protein-coupled receptor 34; Orphan receptor | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | 0.456 |
GPR34 | GPR61 | ENSP00000367378 | ENSP00000385422 | G protein-coupled receptor 34; Orphan receptor | G protein-coupled receptor 61; Orphan receptor | 0.512 |
GPR4 | GPR12 | ENSP00000319744 | ENSP00000370844 | G protein-coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | 0.589 |
GPR61 | GPR12 | ENSP00000385422 | ENSP00000370844 | G protein-coupled receptor 61; Orphan receptor | G protein-coupled receptor 12; Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production | 0.586 |