node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC6 | NOMO2 | ENSP00000205557 | ENSP00000370883 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.676 |
ABCC6 | UBC | ENSP00000205557 | ENSP00000344818 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) | ubiquitin C | 0.444 |
ABCC6 | XYLT1 | ENSP00000205557 | ENSP00000261381 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) | xylosyltransferase I; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes | 0.815 |
ATG4C | NOMO2 | ENSP00000322159 | ENSP00000370883 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.822 |
ATG4C | STT3B | ENSP00000322159 | ENSP00000295770 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae); Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subs [...] | 0.581 |
ATG4C | UBC | ENSP00000322159 | ENSP00000344818 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | ubiquitin C | 0.635 |
CAD | NOMO2 | ENSP00000264705 | ENSP00000370883 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.711 |
CAD | UBC | ENSP00000264705 | ENSP00000344818 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ubiquitin C | 0.874 |
DOHH | NOMO2 | ENSP00000250937 | ENSP00000370883 | deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.595 |
DOHH | UBC | ENSP00000250937 | ENSP00000344818 | deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor | ubiquitin C | 0.509 |
KDELR1 | NOMO2 | ENSP00000329471 | ENSP00000370883 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.592 |
KDELR1 | UBC | ENSP00000329471 | ENSP00000344818 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L | ubiquitin C | 0.541 |
NCLN | NOMO2 | ENSP00000246117 | ENSP00000370883 | nicalin | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | 0.937 |
NCLN | TMEM147 | ENSP00000246117 | ENSP00000222284 | nicalin | transmembrane protein 147 | 0.979 |
NCLN | UBC | ENSP00000246117 | ENSP00000344818 | nicalin | ubiquitin C | 0.938 |
NCLN | XYLT1 | ENSP00000246117 | ENSP00000261381 | nicalin | xylosyltransferase I; Catalyzes the first step in biosynthesis of glycosaminoglycan. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Initial enzyme in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans in fibroblasts and chondrocytes | 0.527 |
NOMO2 | ABCC6 | ENSP00000370883 | ENSP00000205557 | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | ATP-binding cassette, sub-family C (CFTR/MRP), member 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) | 0.676 |
NOMO2 | ATG4C | ENSP00000370883 | ENSP00000322159 | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.822 |
NOMO2 | CAD | ENSP00000370883 | ENSP00000264705 | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.711 |
NOMO2 | DOHH | ENSP00000370883 | ENSP00000250937 | NODAL modulator 2; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity) | deoxyhypusine hydroxylase/monooxygenase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor | 0.595 |