node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRYZL1 | EFHC2 | ENSP00000370966 | ENSP00000333823 | crystallin, zeta (quinone reductase)-like 1 | EF-hand domain (C-terminal) containing 2 | 0.661 |
CRYZL1 | ELK1 | ENSP00000370966 | ENSP00000247161 | crystallin, zeta (quinone reductase)-like 1 | ELK1, member of ETS oncogene family; Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element | 0.661 |
CRYZL1 | FRMD7 | ENSP00000370966 | ENSP00000298542 | crystallin, zeta (quinone reductase)-like 1 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.743 |
CRYZL1 | ITSN1 | ENSP00000370966 | ENSP00000370719 | crystallin, zeta (quinone reductase)-like 1 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | 0.690 |
CRYZL1 | MAOA | ENSP00000370966 | ENSP00000340684 | crystallin, zeta (quinone reductase)-like 1 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | 0.777 |
CRYZL1 | MAOB | ENSP00000370966 | ENSP00000367309 | crystallin, zeta (quinone reductase)-like 1 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | 0.774 |
CRYZL1 | NDP | ENSP00000370966 | ENSP00000367301 | crystallin, zeta (quinone reductase)-like 1 | Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] | 0.755 |
CRYZL1 | NTMT1 | ENSP00000370966 | ENSP00000361558 | crystallin, zeta (quinone reductase)-like 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and mono- or di- methylation of Pro in the Pro-Pro-Lys motif. Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation vi [...] | 0.644 |
CRYZL1 | NYX | ENSP00000370966 | ENSP00000340328 | crystallin, zeta (quinone reductase)-like 1 | nyctalopin | 0.756 |
CRYZL1 | ZADH2 | ENSP00000370966 | ENSP00000323678 | crystallin, zeta (quinone reductase)-like 1 | zinc binding alcohol dehydrogenase domain containing 2 | 0.755 |
EFHC2 | CRYZL1 | ENSP00000333823 | ENSP00000370966 | EF-hand domain (C-terminal) containing 2 | crystallin, zeta (quinone reductase)-like 1 | 0.661 |
ELK1 | CRYZL1 | ENSP00000247161 | ENSP00000370966 | ELK1, member of ETS oncogene family; Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element | crystallin, zeta (quinone reductase)-like 1 | 0.661 |
FRMD7 | CRYZL1 | ENSP00000298542 | ENSP00000370966 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | crystallin, zeta (quinone reductase)-like 1 | 0.743 |
FRMD7 | NDP | ENSP00000298542 | ENSP00000367301 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] | 0.604 |
FRMD7 | NYX | ENSP00000298542 | ENSP00000340328 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | nyctalopin | 0.758 |
ITSN1 | CRYZL1 | ENSP00000370719 | ENSP00000370966 | intersectin 1 (SH3 domain protein); Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2. Isoform 1 could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1 | crystallin, zeta (quinone reductase)-like 1 | 0.690 |
MAOA | CRYZL1 | ENSP00000340684 | ENSP00000370966 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | crystallin, zeta (quinone reductase)-like 1 | 0.777 |
MAOA | NDP | ENSP00000340684 | ENSP00000367301 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | Norrie disease (pseudoglioma); Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and pr [...] | 0.753 |
MAOA | NYX | ENSP00000340684 | ENSP00000340328 | monoamine oxidase A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine | nyctalopin | 0.457 |
MAOB | CRYZL1 | ENSP00000367309 | ENSP00000370966 | monoamine oxidase B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine | crystallin, zeta (quinone reductase)-like 1 | 0.774 |