COMMD8 protein (Homo sapiens) - STRING network view

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Score

COMMD8

COMM domain containing 8 (183 aa)

Predicted Functional Partners:

COMMD7

0.997

COMMD10

0.992

COMMD3

0.750

UBC

0.721

CUL1

0.574

CUL3

0.574

COMMD1

0.513

CCDC74B

0.507

CCDC22

0.472

COMMD4

0.450

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC22	COMMD10	ENSP00000365401	ENSP00000274458	coiled-coil domain containing 22	COMM domain containing 10	0.669
CCDC22	COMMD8	ENSP00000365401	ENSP00000370984	coiled-coil domain containing 22	COMM domain containing 8	0.472
CCDC74B	COMMD8	ENSP00000308873	ENSP00000370984	coiled-coil domain containing 74B	COMM domain containing 8	0.507
COMMD1	COMMD10	ENSP00000308236	ENSP00000274458	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	COMM domain containing 10	0.514
COMMD1	COMMD4	ENSP00000308236	ENSP00000267935	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	COMM domain containing 4; Down-regulates activation of NF-kappa-B	0.618
COMMD1	COMMD7	ENSP00000308236	ENSP00000278980	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity	0.716
COMMD1	COMMD8	ENSP00000308236	ENSP00000370984	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	COMM domain containing 8	0.513
COMMD1	CUL1	ENSP00000308236	ENSP00000326804	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	cullin 1; Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate [...]	0.830
COMMD1	CUL3	ENSP00000308236	ENSP00000264414	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	cullin 3; Core component of multiple cullin-RING-based BCR (BTB- CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the BCR comple [...]	0.580
COMMD1	UBC	ENSP00000308236	ENSP00000344818	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	ubiquitin C	0.994
COMMD10	CCDC22	ENSP00000274458	ENSP00000365401	COMM domain containing 10	coiled-coil domain containing 22	0.669
COMMD10	COMMD1	ENSP00000274458	ENSP00000308236	COMM domain containing 10	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	0.514
COMMD10	COMMD7	ENSP00000274458	ENSP00000278980	COMM domain containing 10	COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity	0.993
COMMD10	COMMD8	ENSP00000274458	ENSP00000370984	COMM domain containing 10	COMM domain containing 8	0.992
COMMD3	COMMD8	ENSP00000366032	ENSP00000370984	COMM domain containing 3; May down-regulate activation of NF-kappa-B	COMM domain containing 8	0.750
COMMD3	UBC	ENSP00000366032	ENSP00000344818	COMM domain containing 3; May down-regulate activation of NF-kappa-B	ubiquitin C	0.804
COMMD4	COMMD1	ENSP00000267935	ENSP00000308236	COMM domain containing 4; Down-regulates activation of NF-kappa-B	copper metabolism (Murr1) domain containing 1; Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes	0.618
COMMD4	COMMD7	ENSP00000267935	ENSP00000278980	COMM domain containing 4; Down-regulates activation of NF-kappa-B	COMM domain containing 7; Associates with the NF-kappa-B complex and suppresses its transcriptional activity	0.560
COMMD4	COMMD8	ENSP00000267935	ENSP00000370984	COMM domain containing 4; Down-regulates activation of NF-kappa-B	COMM domain containing 8	0.450
COMMD4	UBC	ENSP00000267935	ENSP00000344818	COMM domain containing 4; Down-regulates activation of NF-kappa-B	ubiquitin C	0.854

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