| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD274 | CD3D | ENSP00000370989 | ENSP00000300692 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD3E | ENSP00000370989 | ENSP00000354566 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD3G | ENSP00000370989 | ENSP00000431445 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.900 |
| CD274 | CD80 | ENSP00000370989 | ENSP00000264246 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | 0.915 |
| CD274 | HLA-DRB1 | ENSP00000370989 | ENSP00000353099 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | major histocompatibility complex, class II, DR beta 1 | 0.900 |
| CD274 | HLA-DRB5 | ENSP00000370989 | ENSP00000364114 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | major histocompatibility complex, class II, DR beta 5 | 0.900 |
| CD274 | LCK | ENSP00000370989 | ENSP00000337825 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | lymphocyte-specific protein tyrosine kinase | 0.911 |
| CD274 | PDCD1 | ENSP00000370989 | ENSP00000335062 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | programmed cell death 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors | 0.999 |
| CD274 | PDCD1LG2 | ENSP00000370989 | ENSP00000380855 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity) | 0.914 |
| CD274 | PTPN11 | ENSP00000370989 | ENSP00000340944 | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.968 |
| CD3D | CD274 | ENSP00000300692 | ENSP00000370989 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD274 molecule; Involved in the costimulatory signal, essential for T- cell proliferation and production of IL10 and IFNG, in an IL2- dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production | 0.900 |
| CD3D | CD3E | ENSP00000300692 | ENSP00000354566 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3e molecule, epsilon (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.999 |
| CD3D | CD3G | ENSP00000300692 | ENSP00000431445 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD3g molecule, gamma (CD3-TCR complex); The CD3 complex mediates signal transduction | 0.965 |
| CD3D | CD80 | ENSP00000300692 | ENSP00000264246 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | 0.911 |
| CD3D | HLA-DRB1 | ENSP00000300692 | ENSP00000353099 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | major histocompatibility complex, class II, DR beta 1 | 0.903 |
| CD3D | HLA-DRB5 | ENSP00000300692 | ENSP00000364114 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | major histocompatibility complex, class II, DR beta 5 | 0.903 |
| CD3D | LCK | ENSP00000300692 | ENSP00000337825 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | lymphocyte-specific protein tyrosine kinase | 0.924 |
| CD3D | PDCD1 | ENSP00000300692 | ENSP00000335062 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | programmed cell death 1; Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors | 0.901 |
| CD3D | PDCD1LG2 | ENSP00000300692 | ENSP00000380855 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | programmed cell death 1 ligand 2; Involved in the costimulatory signal, essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity) | 0.900 |
| CD3D | PTPN11 | ENSP00000300692 | ENSP00000340944 | CD3d molecule, delta (CD3-TCR complex); The CD3 complex mediates signal transduction | protein tyrosine phosphatase, non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity | 0.900 |
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