| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AATF | AGAP10 | ENSP00000225402 | ENSP00000407436 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | 0.950 |
| AATF | BMS1 | ENSP00000225402 | ENSP00000363642 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | 0.990 |
| AATF | DCAF13 | ENSP00000225402 | ENSP00000297579 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | DDB1 and CUL4 associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.921 |
| AATF | DDX52 | ENSP00000225402 | ENSP00000268854 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 0.918 |
| AATF | KRR1 | ENSP00000225402 | ENSP00000229214 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) | 0.989 |
| AATF | NAT10 | ENSP00000225402 | ENSP00000257829 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division | 0.982 |
| AATF | NOC4L | ENSP00000225402 | ENSP00000328854 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | nucleolar complex associated 4 homolog (S. cerevisiae) | 0.989 |
| AATF | NOL10 | ENSP00000225402 | ENSP00000371101 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | nucleolar protein 10 | 0.995 |
| AATF | PWP2 | ENSP00000225402 | ENSP00000291576 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | PWP2 periodic tryptophan protein homolog (yeast) | 0.972 |
| AATF | WDR36 | ENSP00000225402 | ENSP00000423067 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 | 0.833 |
| AGAP10 | AATF | ENSP00000407436 | ENSP00000225402 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | 0.950 |
| AGAP10 | DCAF13 | ENSP00000407436 | ENSP00000297579 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | DDB1 and CUL4 associated factor 13; Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex | 0.955 |
| AGAP10 | DDX52 | ENSP00000407436 | ENSP00000268854 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 | 0.902 |
| AGAP10 | KRR1 | ENSP00000407436 | ENSP00000229214 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | KRR1, small subunit (SSU) processome component, homolog (yeast); Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity) | 0.952 |
| AGAP10 | NAT10 | ENSP00000407436 | ENSP00000257829 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division | 0.989 |
| AGAP10 | NOC4L | ENSP00000407436 | ENSP00000328854 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | nucleolar complex associated 4 homolog (S. cerevisiae) | 0.921 |
| AGAP10 | NOL10 | ENSP00000407436 | ENSP00000371101 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | nucleolar protein 10 | 0.990 |
| AGAP10 | PWP2 | ENSP00000407436 | ENSP00000291576 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | PWP2 periodic tryptophan protein homolog (yeast) | 0.975 |
| AGAP10 | WDR36 | ENSP00000407436 | ENSP00000423067 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 10; Putative GTPase-activating protein (Potential) | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 | 0.982 |
| BMS1 | AATF | ENSP00000363642 | ENSP00000225402 | BMS1 homolog, ribosome assembly protein (yeast); May act as a molecular switch during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | 0.990 |
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