GCAT protein (Homo sapiens) - STRING network view

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Score

GCAT

glycine C-acetyltransferase (445 aa)

Predicted Functional Partners:

GLDC

0.925

ALAS1

0.912

ALAS2

0.909

PIPOX

0.907

SHMT2

0.907

SHMT1

0.904

AGXT

0.903

GATM

0.901

GNMT

0.900

SARDH

0.900

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGXT	ALAS1	ENSP00000302620	ENSP00000309259	alanine-glyoxylate aminotransferase	aminolevulinate, delta-, synthase 1	0.906
AGXT	ALAS2	ENSP00000302620	ENSP00000332369	alanine-glyoxylate aminotransferase	aminolevulinate, delta-, synthase 2	0.906
AGXT	GATM	ENSP00000302620	ENSP00000379895	alanine-glyoxylate aminotransferase	glycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis	0.918
AGXT	GCAT	ENSP00000302620	ENSP00000371110	alanine-glyoxylate aminotransferase	glycine C-acetyltransferase	0.903
AGXT	GLDC	ENSP00000302620	ENSP00000370737	alanine-glyoxylate aminotransferase	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.965
AGXT	GNMT	ENSP00000302620	ENSP00000361894	alanine-glyoxylate aminotransferase	glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine	0.910
AGXT	PIPOX	ENSP00000302620	ENSP00000317721	alanine-glyoxylate aminotransferase	pipecolic acid oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline	0.907
AGXT	SARDH	ENSP00000302620	ENSP00000360938	alanine-glyoxylate aminotransferase	sarcosine dehydrogenase	0.929
AGXT	SHMT1	ENSP00000302620	ENSP00000318868	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.963
AGXT	SHMT2	ENSP00000302620	ENSP00000333667	alanine-glyoxylate aminotransferase	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.961
ALAS1	AGXT	ENSP00000309259	ENSP00000302620	aminolevulinate, delta-, synthase 1	alanine-glyoxylate aminotransferase	0.906
ALAS1	ALAS2	ENSP00000309259	ENSP00000332369	aminolevulinate, delta-, synthase 1	aminolevulinate, delta-, synthase 2	0.807
ALAS1	GATM	ENSP00000309259	ENSP00000379895	aminolevulinate, delta-, synthase 1	glycine amidinotransferase (L-arginine-glycine amidinotransferase); Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis	0.900
ALAS1	GCAT	ENSP00000309259	ENSP00000371110	aminolevulinate, delta-, synthase 1	glycine C-acetyltransferase	0.912
ALAS1	GLDC	ENSP00000309259	ENSP00000370737	aminolevulinate, delta-, synthase 1	glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein	0.913
ALAS1	GNMT	ENSP00000309259	ENSP00000361894	aminolevulinate, delta-, synthase 1	glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine	0.900
ALAS1	PIPOX	ENSP00000309259	ENSP00000317721	aminolevulinate, delta-, synthase 1	pipecolic acid oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline	0.900
ALAS1	SARDH	ENSP00000309259	ENSP00000360938	aminolevulinate, delta-, synthase 1	sarcosine dehydrogenase	0.907
ALAS1	SHMT1	ENSP00000309259	ENSP00000318868	aminolevulinate, delta-, synthase 1	serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity)	0.910
ALAS1	SHMT2	ENSP00000309259	ENSP00000333667	aminolevulinate, delta-, synthase 1	serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA	0.903

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