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STRINGSTRING
PHF1 PHF1 SUZ12 SUZ12 JAZF1 JAZF1 BCOR BCOR ZC3H7A ZC3H7A FAM22A FAM22A YWHAE YWHAE IRF2BP2 IRF2BP2 WWTR1 WWTR1 CAMTA1 CAMTA1
"FAM22A" - family with sequence similarity 22, member A in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
FAM22Afamily with sequence similarity 22, member A (878 aa)    
Predicted Functional Partners:
YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide (255 aa)
            score_image   0.659
JAZF1
JAZF zinc finger 1; Potential transcription factor (243 aa)
            score_image   0.617
ZC3H7A
zinc finger CCCH-type containing 7A (971 aa)
            score_image   0.580
PHF1
PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] (567 aa)
            score_image   0.501
IRF2BP2
interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle (587 aa)
            score_image   0.499
SUZ12
suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (739 aa)
            score_image   0.470
WWTR1
WW domain containing transcription regulator 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 an [...] (400 aa)
            score_image   0.459
CAMTA1
calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor (1673 aa)
            score_image   0.456
BCOR
BCL6 corepressor (1755 aa)
            score_image   0.405
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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