node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCOR | FAM22A | ENSP00000367705 | ENSP00000371126 | BCL6 corepressor | family with sequence similarity 22, member A | 0.405 |
CAMTA1 | FAM22A | ENSP00000306522 | ENSP00000371126 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | family with sequence similarity 22, member A | 0.456 |
CAMTA1 | WWTR1 | ENSP00000306522 | ENSP00000353847 | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | WW domain containing transcription regulator 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 an [...] | 0.620 |
FAM22A | BCOR | ENSP00000371126 | ENSP00000367705 | family with sequence similarity 22, member A | BCL6 corepressor | 0.405 |
FAM22A | CAMTA1 | ENSP00000371126 | ENSP00000306522 | family with sequence similarity 22, member A | calmodulin binding transcription activator 1; Transcriptional activator. May act as a tumor suppressor | 0.456 |
FAM22A | IRF2BP2 | ENSP00000371126 | ENSP00000355568 | family with sequence similarity 22, member A | interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle | 0.499 |
FAM22A | JAZF1 | ENSP00000371126 | ENSP00000283928 | family with sequence similarity 22, member A | JAZF zinc finger 1; Potential transcription factor | 0.617 |
FAM22A | PHF1 | ENSP00000371126 | ENSP00000363640 | family with sequence similarity 22, member A | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | 0.501 |
FAM22A | SUZ12 | ENSP00000371126 | ENSP00000316578 | family with sequence similarity 22, member A | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.470 |
FAM22A | WWTR1 | ENSP00000371126 | ENSP00000353847 | family with sequence similarity 22, member A | WW domain containing transcription regulator 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 an [...] | 0.459 |
FAM22A | YWHAE | ENSP00000371126 | ENSP00000264335 | family with sequence similarity 22, member A | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.659 |
FAM22A | ZC3H7A | ENSP00000371126 | ENSP00000347999 | family with sequence similarity 22, member A | zinc finger CCCH-type containing 7A | 0.580 |
IRF2BP2 | FAM22A | ENSP00000355568 | ENSP00000371126 | interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle | family with sequence similarity 22, member A | 0.499 |
IRF2BP2 | ZC3H7A | ENSP00000355568 | ENSP00000347999 | interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle | zinc finger CCCH-type containing 7A | 0.408 |
JAZF1 | FAM22A | ENSP00000283928 | ENSP00000371126 | JAZF zinc finger 1; Potential transcription factor | family with sequence similarity 22, member A | 0.617 |
JAZF1 | PHF1 | ENSP00000283928 | ENSP00000363640 | JAZF zinc finger 1; Potential transcription factor | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | 0.566 |
JAZF1 | SUZ12 | ENSP00000283928 | ENSP00000316578 | JAZF zinc finger 1; Potential transcription factor | suppressor of zeste 12 homolog (Drosophila); Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ (H3K9me) and ’Lys-27’ (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A | 0.701 |
JAZF1 | YWHAE | ENSP00000283928 | ENSP00000264335 | JAZF zinc finger 1; Potential transcription factor | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 0.447 |
PHF1 | FAM22A | ENSP00000363640 | ENSP00000371126 | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | family with sequence similarity 22, member A | 0.501 |
PHF1 | JAZF1 | ENSP00000363640 | ENSP00000283928 | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at ’Lys-36’ (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex- it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | JAZF zinc finger 1; Potential transcription factor | 0.566 |