ARRDC5 protein (Homo sapiens) - STRING network view

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ARRDC5

arrestin domain containing 5 (342 aa)

Predicted Functional Partners:

GAS7

0.598

WWP2

0.576

NEDD4L

0.562

ITCH

0.558

HECW1

0.552

BAG3

0.552

SMURF1

0.552

NEDD4

0.552

YAP1

0.552

WWP1

0.552

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRDC5	BAG3	ENSP00000371200	ENSP00000358081	arrestin domain containing 5	BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity	0.552
ARRDC5	GAS7	ENSP00000371200	ENSP00000407552	arrestin domain containing 5	growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons	0.598
ARRDC5	HECW1	ENSP00000371200	ENSP00000379228	arrestin domain containing 5	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS	0.552
ARRDC5	ITCH	ENSP00000371200	ENSP00000363998	arrestin domain containing 5	itchy E3 ubiquitin protein ligase	0.558
ARRDC5	NEDD4	ENSP00000371200	ENSP00000345530	arrestin domain containing 5	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	0.552
ARRDC5	NEDD4L	ENSP00000371200	ENSP00000383199	arrestin domain containing 5	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	0.562
ARRDC5	SMURF1	ENSP00000371200	ENSP00000354621	arrestin domain containing 5	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA	0.552
ARRDC5	WWP1	ENSP00000371200	ENSP00000265428	arrestin domain containing 5	WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...]	0.552
ARRDC5	WWP2	ENSP00000371200	ENSP00000348283	arrestin domain containing 5	WW domain containing E3 ubiquitin protein ligase 2	0.576
ARRDC5	YAP1	ENSP00000371200	ENSP00000282441	arrestin domain containing 5	Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...]	0.552
BAG3	ARRDC5	ENSP00000358081	ENSP00000371200	BCL2-associated athanogene 3; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity	arrestin domain containing 5	0.552
GAS7	ARRDC5	ENSP00000407552	ENSP00000371200	growth arrest-specific 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons	arrestin domain containing 5	0.598
HECW1	ARRDC5	ENSP00000379228	ENSP00000371200	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS	arrestin domain containing 5	0.552
ITCH	ARRDC5	ENSP00000363998	ENSP00000371200	itchy E3 ubiquitin protein ligase	arrestin domain containing 5	0.558
ITCH	WWP1	ENSP00000363998	ENSP00000265428	itchy E3 ubiquitin protein ligase	WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...]	0.901
ITCH	YAP1	ENSP00000363998	ENSP00000282441	itchy E3 ubiquitin protein ligase	Yes-associated protein 1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and [...]	0.582
NEDD4	ARRDC5	ENSP00000345530	ENSP00000371200	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	arrestin domain containing 5	0.552
NEDD4L	ARRDC5	ENSP00000383199	ENSP00000371200	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	arrestin domain containing 5	0.562
NEDD4L	SMURF1	ENSP00000383199	ENSP00000354621	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	SMAD specific E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA	0.908
NEDD4L	WWP1	ENSP00000383199	ENSP00000265428	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	WW domain containing E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in resp [...]	0.929

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