METTL22 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

METTL22

methyltransferase like 22; Probable methyltransferase (By similarity) (404 aa)

Predicted Functional Partners:

KIN

0.898

ZNF570

0.701

METTL20

0.692

GLOD5

0.649

METTL23

0.614

METTL18

0.601

GRWD1

0.586

FOXK1

0.550

FAM86B1

0.485

FAM86A

0.485

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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structured XML interaction data, according to the 'PSI-MI' data standard

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... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM86A	METTL18	ENSP00000398502	ENSP00000307077	family with sequence similarity 86, member A	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	0.485
FAM86A	METTL22	ENSP00000398502	ENSP00000371345	family with sequence similarity 86, member A	methyltransferase like 22; Probable methyltransferase (By similarity)	0.485
FAM86B1	METTL18	ENSP00000432931	ENSP00000307077	family with sequence similarity 86, member B1	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	0.485
FAM86B1	METTL22	ENSP00000432931	ENSP00000371345	family with sequence similarity 86, member B1	methyltransferase like 22; Probable methyltransferase (By similarity)	0.485
FOXK1	METTL22	ENSP00000328720	ENSP00000371345	forkhead box K1; Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Has a role in myogenic differentiation and in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity)	methyltransferase like 22; Probable methyltransferase (By similarity)	0.550
GLOD5	METTL22	ENSP00000302552	ENSP00000371345	glyoxalase domain containing 5	methyltransferase like 22; Probable methyltransferase (By similarity)	0.649
GLOD5	ZNF570	ENSP00000302552	ENSP00000331540	glyoxalase domain containing 5	zinc finger protein 570; May be involved in transcriptional regulation	0.813
GRWD1	METTL18	ENSP00000253237	ENSP00000307077	glutamate-rich WD repeat containing 1	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	0.720
GRWD1	METTL20	ENSP00000253237	ENSP00000350353	glutamate-rich WD repeat containing 1	methyltransferase like 20; Probable methyltransferase (By similarity)	0.644
GRWD1	METTL22	ENSP00000253237	ENSP00000371345	glutamate-rich WD repeat containing 1	methyltransferase like 22; Probable methyltransferase (By similarity)	0.586
GRWD1	METTL23	ENSP00000253237	ENSP00000341543	glutamate-rich WD repeat containing 1	methyltransferase like 23; Probable methyltransferase (By similarity)	0.580
KIN	METTL22	ENSP00000368881	ENSP00000371345	KIN, antigenic determinant of recA protein homolog (mouse); Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro	methyltransferase like 22; Probable methyltransferase (By similarity)	0.898
METTL18	FAM86A	ENSP00000307077	ENSP00000398502	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	family with sequence similarity 86, member A	0.485
METTL18	FAM86B1	ENSP00000307077	ENSP00000432931	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	family with sequence similarity 86, member B1	0.485
METTL18	GRWD1	ENSP00000307077	ENSP00000253237	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	glutamate-rich WD repeat containing 1	0.720
METTL18	METTL20	ENSP00000307077	ENSP00000350353	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	methyltransferase like 20; Probable methyltransferase (By similarity)	0.671
METTL18	METTL22	ENSP00000307077	ENSP00000371345	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	methyltransferase like 22; Probable methyltransferase (By similarity)	0.601
METTL18	METTL23	ENSP00000307077	ENSP00000341543	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	methyltransferase like 23; Probable methyltransferase (By similarity)	0.612
METTL20	GRWD1	ENSP00000350353	ENSP00000253237	methyltransferase like 20; Probable methyltransferase (By similarity)	glutamate-rich WD repeat containing 1	0.644
METTL20	METTL18	ENSP00000350353	ENSP00000307077	methyltransferase like 20; Probable methyltransferase (By similarity)	methyltransferase like 18; Probable histidine methyltransferase (By similarity)	0.671

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