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STRINGSTRING
MEF2A MEF2A MEF2D MEF2D MEF2C MEF2C SLC1A1 SLC1A1 SUFU SUFU GLIS3 GLIS3 NEUROG3 NEUROG3 DGKB DGKB ADCY5 ADCY5 AGMO AGMO C2CD4B C2CD4B
"GLIS3" - GLIS family zinc finger 3 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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homology edge
protein homology
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[Homology]
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GLIS3GLIS family zinc finger 3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5’-GACCACCCAC-3’ (By similarity) (930 aa)    
Predicted Functional Partners:
NEUROG3
neurogenin 3; Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity) (214 aa)
            score_image   0.834
SUFU
suppressor of fused homolog (Drosophila); Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full len [...] (484 aa)
        score_image   score_image   0.767
MEF2A
myocyte enhancer factor 2A (499 aa)
        score_image   score_image   0.759
MEF2C
myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...] (483 aa)
        score_image   score_image   0.759
MEF2D
myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity) (521 aa)
        score_image   score_image   0.759
DGKB
diacylglycerol kinase, beta 90kDa (804 aa)
      score_image     score_image   0.730
AGMO
alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (445 aa)
            score_image   0.720
C2CD4B
C2 calcium-dependent domain containing 4B; May be involved in inflammatory process. May regulate cell architecture and adhesion (364 aa)
            score_image   0.704
SLC1A1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity) (524 aa)
            score_image   0.655
ADCY5
adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)
      score_image score_image   score_image   0.647
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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