| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHST15 | GPNMB | ENSP00000333947 | ENSP00000371420 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15; Sulfotransferase that transfers sulfate from 3’- phosphoadenosine 5’-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in [...] | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | 0.742 |
| EGFR | EPCAM | ENSP00000275493 | ENSP00000263735 | epidermal growth factor receptor | epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E | 0.581 |
| EGFR | FGF2 | ENSP00000275493 | ENSP00000264498 | epidermal growth factor receptor | fibroblast growth factor 2 (basic) | 0.992 |
| EGFR | GPNMB | ENSP00000275493 | ENSP00000371420 | epidermal growth factor receptor | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | 0.720 |
| EGFR | MMP3 | ENSP00000275493 | ENSP00000299855 | epidermal growth factor receptor | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | 0.551 |
| EGFR | TP53 | ENSP00000275493 | ENSP00000269305 | epidermal growth factor receptor | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.997 |
| EPCAM | EGFR | ENSP00000263735 | ENSP00000275493 | epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E | epidermal growth factor receptor | 0.581 |
| EPCAM | GPNMB | ENSP00000263735 | ENSP00000371420 | epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | 0.910 |
| EPCAM | TP53 | ENSP00000263735 | ENSP00000269305 | epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.908 |
| ERVW-1 | GPNMB | ENSP00000419945 | ENSP00000371420 | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | 0.811 |
| ERVW-1 | ITIH4 | ENSP00000419945 | ENSP00000266041 | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | inter-alpha-trypsin inhibitor heavy chain family, member 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration | 0.988 |
| ERVW-1 | TP53 | ENSP00000419945 | ENSP00000269305 | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.454 |
| FGF2 | EGFR | ENSP00000264498 | ENSP00000275493 | fibroblast growth factor 2 (basic) | epidermal growth factor receptor | 0.992 |
| FGF2 | GPNMB | ENSP00000264498 | ENSP00000371420 | fibroblast growth factor 2 (basic) | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | 0.825 |
| FGF2 | MMP3 | ENSP00000264498 | ENSP00000299855 | fibroblast growth factor 2 (basic) | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | 0.913 |
| FGF2 | TP53 | ENSP00000264498 | ENSP00000269305 | fibroblast growth factor 2 (basic) | tumor protein p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) | 0.941 |
| GPNMB | CHST15 | ENSP00000371420 | ENSP00000333947 | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15; Sulfotransferase that transfers sulfate from 3’- phosphoadenosine 5’-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in [...] | 0.742 |
| GPNMB | EGFR | ENSP00000371420 | ENSP00000275493 | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | epidermal growth factor receptor | 0.720 |
| GPNMB | EPCAM | ENSP00000371420 | ENSP00000263735 | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E | 0.910 |
| GPNMB | ERVW-1 | ENSP00000371420 | ENSP00000419945 | glycoprotein (transmembrane) nmb; Could be a melanogenic enzyme (By similarity) | endogenous retrovirus group W, member 1; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties and participates in trophoblast fusion during placenta morphogenesis | 0.811 |
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