MIPEP protein (Homo sapiens) - STRING network view

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Score

MIPEP

mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size (713 aa)

Predicted Functional Partners:

FXN

0.778

HBS1L

0.757

HBG1

0.683

FECH

0.661

SMTNL2

0.645

OXA1L

0.639

LAP3

0.517

HBG2

0.513

TFAP4

0.511

SLC25A24

0.484

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FECH	FXN	ENSP00000372326	ENSP00000366482	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...]	0.924
FECH	MIPEP	ENSP00000372326	ENSP00000371607	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.661
FXN	FECH	ENSP00000366482	ENSP00000372326	frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...]	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	0.924
FXN	MIPEP	ENSP00000366482	ENSP00000371607	frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...]	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.778
HBG1	HBS1L	ENSP00000327431	ENSP00000356811	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	HBS1-like (S. cerevisiae)	0.610
HBG1	MIPEP	ENSP00000327431	ENSP00000371607	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.683
HBG1	TFAP4	ENSP00000327431	ENSP00000204517	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	transcription factor AP-4 (activating enhancer binding protein 4); Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5’- CAGCTG-3’	0.610
HBG2	HBS1L	ENSP00000338082	ENSP00000356811	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	HBS1-like (S. cerevisiae)	0.626
HBG2	MIPEP	ENSP00000338082	ENSP00000371607	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.513
HBG2	TFAP4	ENSP00000338082	ENSP00000204517	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	transcription factor AP-4 (activating enhancer binding protein 4); Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5’- CAGCTG-3’	0.440
HBS1L	HBG1	ENSP00000356811	ENSP00000327431	HBS1-like (S. cerevisiae)	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.610
HBS1L	HBG2	ENSP00000356811	ENSP00000338082	HBS1-like (S. cerevisiae)	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.626
HBS1L	MIPEP	ENSP00000356811	ENSP00000371607	HBS1-like (S. cerevisiae)	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.757
HBS1L	TFAP4	ENSP00000356811	ENSP00000204517	HBS1-like (S. cerevisiae)	transcription factor AP-4 (activating enhancer binding protein 4); Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5’- CAGCTG-3’	0.747
LAP3	MIPEP	ENSP00000226299	ENSP00000371607	leucine aminopeptidase 3; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	0.517
MIPEP	FECH	ENSP00000371607	ENSP00000372326	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	0.661
MIPEP	FXN	ENSP00000371607	ENSP00000366482	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...]	0.778
MIPEP	HBG1	ENSP00000371607	ENSP00000327431	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.683
MIPEP	HBG2	ENSP00000371607	ENSP00000338082	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	hemoglobin, gamma G; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.513
MIPEP	HBS1L	ENSP00000371607	ENSP00000356811	mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size	HBS1-like (S. cerevisiae)	0.757

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