| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD44 | SACS | ENSP00000398632 | ENSP00000371729 | CD44 molecule (Indian blood group) | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.801 |
| CD44 | UBC | ENSP00000398632 | ENSP00000344818 | CD44 molecule (Indian blood group) | ubiquitin C | 0.908 |
| IL16 | SACS | ENSP00000302935 | ENSP00000371729 | interleukin 16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.801 |
| MUC5B | SACS | ENSP00000436812 | ENSP00000371729 | mucin 5B, oligomeric mucus/gel-forming | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.564 |
| NARS | SACS | ENSP00000256854 | ENSP00000371729 | asparaginyl-tRNA synthetase | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.608 |
| NARS | UBC | ENSP00000256854 | ENSP00000344818 | asparaginyl-tRNA synthetase | ubiquitin C | 0.975 |
| PES1 | SACS | ENSP00000346725 | ENSP00000371729 | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.610 |
| PES1 | SGCG | ENSP00000346725 | ENSP00000218867 | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.705 |
| PES1 | UBC | ENSP00000346725 | ENSP00000344818 | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | ubiquitin C | 0.958 |
| PSMA3 | SACS | ENSP00000216455 | ENSP00000371729 | proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | 0.576 |
| PSMA3 | UBC | ENSP00000216455 | ENSP00000344818 | proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2 | ubiquitin C | 0.998 |
| SACS | CD44 | ENSP00000371729 | ENSP00000398632 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | CD44 molecule (Indian blood group) | 0.801 |
| SACS | IL16 | ENSP00000371729 | ENSP00000302935 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | interleukin 16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4 | 0.801 |
| SACS | MUC5B | ENSP00000371729 | ENSP00000436812 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | mucin 5B, oligomeric mucus/gel-forming | 0.564 |
| SACS | NARS | ENSP00000371729 | ENSP00000256854 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | asparaginyl-tRNA synthetase | 0.608 |
| SACS | PES1 | ENSP00000371729 | ENSP00000346725 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | pescadillo ribosomal biogenesis factor 1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.610 |
| SACS | PSMA3 | ENSP00000371729 | ENSP00000216455 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | proteasome (prosome, macropain) subunit, alpha type, 3; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2 | 0.576 |
| SACS | SGCG | ENSP00000371729 | ENSP00000218867 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein); Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix | 0.607 |
| SACS | TRPC1 | ENSP00000371729 | ENSP00000273482 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | transient receptor potential cation channel, subfamily C, member 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion | 0.551 |
| SACS | UBC | ENSP00000371729 | ENSP00000344818 | spastic ataxia of Charlevoix-Saguenay (sacsin); Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins | ubiquitin C | 0.911 |
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