node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACLY | DAZ3 | ENSP00000253792 | ENSP00000371802 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | 0.585 |
ACLY | SNRNP35 | ENSP00000253792 | ENSP00000403310 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | small nuclear ribonucleoprotein 35kDa (U11/U12) | 0.585 |
ACLY | SNRNP70 | ENSP00000253792 | ENSP00000472998 | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | small nuclear ribonucleoprotein 70kDa (U1) | 0.585 |
DAZ3 | ACLY | ENSP00000371802 | ENSP00000253792 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.585 |
DAZ3 | DHX8 | ENSP00000371802 | ENSP00000262415 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.610 |
DAZ3 | PUM2 | ENSP00000371802 | ENSP00000338173 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | pumilio homolog 2 (Drosophila); Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3’-UTR of mRNA targets. Its interactions and tissue specificity suggest that it may be required to support proliferation and self-renewal of stem cells by regulating the translation of key transcripts | 0.663 |
DAZ3 | RNPC3 | ENSP00000371802 | ENSP00000391432 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | RNA-binding region (RNP1, RRM) containing 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA | 0.599 |
DAZ3 | SNRNP35 | ENSP00000371802 | ENSP00000403310 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | small nuclear ribonucleoprotein 35kDa (U11/U12) | 0.601 |
DAZ3 | SNRNP70 | ENSP00000371802 | ENSP00000472998 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | small nuclear ribonucleoprotein 70kDa (U1) | 0.601 |
DAZ3 | SNRPA | ENSP00000371802 | ENSP00000243563 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | small nuclear ribonucleoprotein polypeptide A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5’-UGCAC-3’ motif in vitro | 0.616 |
DAZ3 | SNRPB2 | ENSP00000371802 | ENSP00000246071 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | small nuclear ribonucleoprotein polypeptide B; Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A’ protein | 0.672 |
DAZ3 | SNRPD3 | ENSP00000371802 | ENSP00000215829 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.580 |
DAZ3 | XAB2 | ENSP00000371802 | ENSP00000351137 | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | XPA binding protein 2; Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing | 0.580 |
DHX8 | DAZ3 | ENSP00000262415 | ENSP00000371802 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | deleted in azoospermia 3; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation | 0.610 |
DHX8 | RNPC3 | ENSP00000262415 | ENSP00000391432 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | RNA-binding region (RNP1, RRM) containing 3; Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3’-stem-loop of m(7)G-capped U12 snRNA | 0.404 |
DHX8 | SNRNP35 | ENSP00000262415 | ENSP00000403310 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | small nuclear ribonucleoprotein 35kDa (U11/U12) | 0.610 |
DHX8 | SNRNP70 | ENSP00000262415 | ENSP00000472998 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | small nuclear ribonucleoprotein 70kDa (U1) | 0.691 |
DHX8 | SNRPA | ENSP00000262415 | ENSP00000243563 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | small nuclear ribonucleoprotein polypeptide A; Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5’-UGCAC-3’ motif in vitro | 0.870 |
DHX8 | SNRPB2 | ENSP00000262415 | ENSP00000246071 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | small nuclear ribonucleoprotein polypeptide B; Involved in pre-mRNA splicing. This protein is associated with snRNP U2. It binds stem loop IV of U2 snRNA only in presence of the U2A’ protein | 0.863 |
DHX8 | SNRPD3 | ENSP00000262415 | ENSP00000215829 | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | small nuclear ribonucleoprotein D3 polypeptide 18kDa; Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner | 0.411 |