node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C22orf32 | CCDC109B | ENSP00000327467 | ENSP00000378145 | chromosome 22 open reading frame 32 | coiled-coil domain containing 109B | 0.959 |
C22orf32 | EFHA1 | ENSP00000327467 | ENSP00000371811 | chromosome 22 open reading frame 32 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.939 |
C22orf32 | MCU | ENSP00000327467 | ENSP00000362144 | chromosome 22 open reading frame 32 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.936 |
C22orf32 | MICU1 | ENSP00000327467 | ENSP00000354415 | chromosome 22 open reading frame 32 | mitochondrial calcium uptake 1 | 0.958 |
CCDC109B | C22orf32 | ENSP00000378145 | ENSP00000327467 | coiled-coil domain containing 109B | chromosome 22 open reading frame 32 | 0.959 |
CCDC109B | EFHA1 | ENSP00000378145 | ENSP00000371811 | coiled-coil domain containing 109B | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.938 |
CCDC109B | MCU | ENSP00000378145 | ENSP00000362144 | coiled-coil domain containing 109B | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.911 |
CCDC109B | MICU1 | ENSP00000378145 | ENSP00000354415 | coiled-coil domain containing 109B | mitochondrial calcium uptake 1 | 0.949 |
CCDC90A | EFHA1 | ENSP00000368468 | ENSP00000371811 | coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.772 |
CCDC90A | LETM1 | ENSP00000368468 | ENSP00000305653 | coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU | leucine zipper-EF-hand containing transmembrane protein 1; Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization | 0.780 |
CCDC90A | MCU | ENSP00000368468 | ENSP00000362144 | coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.648 |
CCDC90A | MICU1 | ENSP00000368468 | ENSP00000354415 | coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU | mitochondrial calcium uptake 1 | 0.843 |
EFHA1 | C22orf32 | ENSP00000371811 | ENSP00000327467 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | chromosome 22 open reading frame 32 | 0.939 |
EFHA1 | CCDC109B | ENSP00000371811 | ENSP00000378145 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | coiled-coil domain containing 109B | 0.938 |
EFHA1 | CCDC90A | ENSP00000371811 | ENSP00000368468 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | coiled-coil domain containing 90A; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU | 0.772 |
EFHA1 | FGF16 | ENSP00000371811 | ENSP00000399324 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | fibroblast growth factor 16 | 0.610 |
EFHA1 | FGF20 | ENSP00000371811 | ENSP00000180166 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | fibroblast growth factor 20; Neurotrophic factor that regulates central nervous development and function | 0.889 |
EFHA1 | FGF9 | ENSP00000371811 | ENSP00000371790 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors | 0.810 |
EFHA1 | LETM1 | ENSP00000371811 | ENSP00000305653 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | leucine zipper-EF-hand containing transmembrane protein 1; Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization | 0.713 |
EFHA1 | MCU | ENSP00000371811 | ENSP00000362144 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.973 |