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DEFB125 DEFB125 DEFB129 DEFB129 DEFB132 DEFB132 DEFB127 DEFB127 DEFB103A DEFB103A DEFB126 DEFB126 TFEC TFEC
"DEFB127" - defensin, beta 127 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
DEFB127defensin, beta 127; Has antibacterial activity (Potential) (99 aa)    
Predicted Functional Partners:
DEFB132
defensin, beta 132; Has antibacterial activity (Potential) (95 aa)
             score_image   0.701
DEFB125
defensin, beta 125; Has antibacterial activity (Potential) (156 aa)
             score_image   0.700
DEFB126
defensin, beta 126; Has antibacterial activity (Potential) (111 aa)
             score_image   0.632
TFEC
transcription factor EC; Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence). Binds to element F in an E-box sequence-specific manner. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter (By similarity). Collaborates with MITF in target gene activation (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By sim [...] (347 aa)
         score_image       0.612
DEFB103A
defensin, beta 103A; Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed (67 aa)
             score_image   0.585
DEFB129
defensin, beta 129; Has antibacterial activity (Potential) (183 aa)
             score_image   0.506
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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