node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP3 | DEAF1 | ENSP00000311032 | ENSP00000371846 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.882 |
CASP3 | EIF4G3 | ENSP00000311032 | ENSP00000364073 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 | 0.909 |
CASP3 | PRKDC | ENSP00000311032 | ENSP00000313420 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | protein kinase, DNA-activated, catalytic polypeptide | 0.973 |
DEAF1 | CASP3 | ENSP00000371846 | ENSP00000311032 | deformed epidermal autoregulatory factor 1 (Drosophila) | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.882 |
DEAF1 | EIF4G3 | ENSP00000371846 | ENSP00000364073 | deformed epidermal autoregulatory factor 1 (Drosophila) | eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 | 0.817 |
DEAF1 | ENSG00000259741 | ENSP00000371846 | ENSP00000452959 | deformed epidermal autoregulatory factor 1 (Drosophila) | zinc finger MYND domain-containing protein 11 isoform g | 0.815 |
DEAF1 | GDF5 | ENSP00000371846 | ENSP00000363489 | deformed epidermal autoregulatory factor 1 (Drosophila) | growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B | 0.822 |
DEAF1 | HTR1A | ENSP00000371846 | ENSP00000316244 | deformed epidermal autoregulatory factor 1 (Drosophila) | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.888 |
DEAF1 | LMO2 | ENSP00000371846 | ENSP00000257818 | deformed epidermal autoregulatory factor 1 (Drosophila) | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | 0.846 |
DEAF1 | LMO4 | ENSP00000371846 | ENSP00000359573 | deformed epidermal autoregulatory factor 1 (Drosophila) | LIM domain only 4; Probable transcriptional factor (By similarity) | 0.750 |
DEAF1 | PRKDC | ENSP00000371846 | ENSP00000313420 | deformed epidermal autoregulatory factor 1 (Drosophila) | protein kinase, DNA-activated, catalytic polypeptide | 0.812 |
DEAF1 | ZMYND11 | ENSP00000371846 | ENSP00000371003 | deformed epidermal autoregulatory factor 1 (Drosophila) | zinc finger, MYND-type containing 11; Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors | 0.757 |
DEAF1 | ZMYND19 | ENSP00000371846 | ENSP00000298585 | deformed epidermal autoregulatory factor 1 (Drosophila) | zinc finger, MYND-type containing 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling | 0.772 |
EIF4G3 | CASP3 | ENSP00000364073 | ENSP00000311032 | eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.909 |
EIF4G3 | DEAF1 | ENSP00000364073 | ENSP00000371846 | eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.817 |
ENSG00000259741 | DEAF1 | ENSP00000452959 | ENSP00000371846 | zinc finger MYND domain-containing protein 11 isoform g | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.815 |
GDF5 | DEAF1 | ENSP00000363489 | ENSP00000371846 | growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.822 |
HTR1A | DEAF1 | ENSP00000316244 | ENSP00000371846 | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.888 |
LMO2 | DEAF1 | ENSP00000257818 | ENSP00000371846 | LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.846 |
LMO4 | DEAF1 | ENSP00000359573 | ENSP00000371846 | LIM domain only 4; Probable transcriptional factor (By similarity) | deformed epidermal autoregulatory factor 1 (Drosophila) | 0.750 |