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STRINGSTRING
ENSG00000259741 ENSG00000259741 GDF5 GDF5 EIF4G3 EIF4G3 CASP3 CASP3 ZMYND11 ZMYND11 DEAF1 DEAF1 PRKDC PRKDC LMO4 LMO4 HTR1A HTR1A LMO2 LMO2 ZMYND19 ZMYND19
"DEAF1" - deformed epidermal autoregulatory factor 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DEAF1deformed epidermal autoregulatory factor 1 (Drosophila) (565 aa)    
Predicted Functional Partners:
HTR1A
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity (422 aa)
            score_image   0.888
CASP3
caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (277 aa)
            score_image   0.882
LMO2
LIM domain only 2 (rhombotin-like 1); Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state (227 aa)
            score_image   0.846
GDF5
growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B (501 aa)
            score_image   0.822
EIF4G3
eukaryotic translation initiation factor 4 gamma, 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5’-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (1591 aa)
            score_image   0.817
ENSG00000259741
zinc finger MYND domain-containing protein 11 isoform g (568 aa)
            score_image   0.815
PRKDC
protein kinase, DNA-activated, catalytic polypeptide (4127 aa)
            score_image   0.812
ZMYND19
zinc finger, MYND-type containing 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling (227 aa)
            score_image   0.772
ZMYND11
zinc finger, MYND-type containing 11; Corepressor of transcription (Probable). May be involved in chromatin remodeling through association with several remodeling factors (602 aa)
            score_image   0.757
LMO4
LIM domain only 4; Probable transcriptional factor (By similarity) (165 aa)
        score_image   score_image   0.750
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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