node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALOX12 | ALOX12B | ENSP00000251535 | ENSP00000315167 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.911 |
ALOX12 | ALOX15B | ENSP00000251535 | ENSP00000369530 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.913 |
ALOX12 | CYP2J2 | ENSP00000251535 | ENSP00000360247 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | 0.914 |
ALOX12 | ENSG00000168970 | ENSP00000251535 | ENSP00000371886 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | JMJD7-PLA2G4B readthrough | 0.912 |
ALOX12 | PTGS2 | ENSP00000251535 | ENSP00000356438 | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.940 |
ALOX12B | ALOX12 | ENSP00000315167 | ENSP00000251535 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | 0.911 |
ALOX12B | ALOX15B | ENSP00000315167 | ENSP00000369530 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.905 |
ALOX12B | CYP2J2 | ENSP00000315167 | ENSP00000360247 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | 0.907 |
ALOX12B | ENSG00000168970 | ENSP00000315167 | ENSP00000371886 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | JMJD7-PLA2G4B readthrough | 0.912 |
ALOX12B | PTGS2 | ENSP00000315167 | ENSP00000356438 | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.938 |
ALOX15B | ALOX12 | ENSP00000369530 | ENSP00000251535 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | 0.913 |
ALOX15B | ALOX12B | ENSP00000369530 | ENSP00000315167 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.905 |
ALOX15B | CYP2J2 | ENSP00000369530 | ENSP00000360247 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | 0.913 |
ALOX15B | ENSG00000168970 | ENSP00000369530 | ENSP00000371886 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | JMJD7-PLA2G4B readthrough | 0.912 |
ALOX15B | PTGS2 | ENSP00000369530 | ENSP00000356438 | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.945 |
CYP2J2 | ALOX12 | ENSP00000360247 | ENSP00000251535 | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | arachidonate 12-lipoxygenase; Oxygenase and 14,15-leukotriene A4 synthase activity | 0.914 |
CYP2J2 | ALOX12B | ENSP00000360247 | ENSP00000315167 | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) | 0.907 |
CYP2J2 | ALOX15B | ENSP00000360247 | ENSP00000369530 | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | arachidonate 15-lipoxygenase, type B; Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized | 0.913 |
CYP2J2 | ENSG00000168970 | ENSP00000360247 | ENSP00000371886 | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | JMJD7-PLA2G4B readthrough | 0.925 |
CYP2J2 | PTGS2 | ENSP00000360247 | ENSP00000356438 | cytochrome P450, family 2, subfamily J, polypeptide 2; This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.913 |