| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BRIX1 | FBL | ENSP00000338862 | ENSP00000221801 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | 0.967 |
| BRIX1 | GNL2 | ENSP00000338862 | ENSP00000362153 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | 0.829 |
| BRIX1 | GTPBP4 | ENSP00000338862 | ENSP00000354040 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.988 |
| BRIX1 | PRMT1 | ENSP00000338862 | ENSP00000406162 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | protein arginine methyltransferase 1 | 0.803 |
| BRIX1 | PRMT8 | ENSP00000338862 | ENSP00000372067 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | 0.803 |
| BRIX1 | TRMT11 | ENSP00000338862 | ENSP00000333934 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.842 |
| EWSR1 | PRMT1 | ENSP00000400142 | ENSP00000406162 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | protein arginine methyltransferase 1 | 0.850 |
| EWSR1 | PRMT8 | ENSP00000400142 | ENSP00000372067 | Ewing sarcoma breakpoint region 1; Might normally function as a transcriptionnal repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | 0.863 |
| FBL | BRIX1 | ENSP00000221801 | ENSP00000338862 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.967 |
| FBL | GNL2 | ENSP00000221801 | ENSP00000362153 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | 0.582 |
| FBL | GTPBP4 | ENSP00000221801 | ENSP00000354040 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.781 |
| FBL | PRMT1 | ENSP00000221801 | ENSP00000406162 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | protein arginine methyltransferase 1 | 0.983 |
| FBL | PRMT5 | ENSP00000221801 | ENSP00000319169 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | protein arginine methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of [...] | 0.959 |
| FBL | PRMT8 | ENSP00000221801 | ENSP00000372067 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | 0.949 |
| FBL | TRMT11 | ENSP00000221801 | ENSP00000333934 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | tRNA methyltransferase 11 homolog (S. cerevisiae); Catalytic subunit of an S-adenosyl-L-methionine- dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs (By similarity) | 0.664 |
| GNL2 | BRIX1 | ENSP00000362153 | ENSP00000338862 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.829 |
| GNL2 | FBL | ENSP00000362153 | ENSP00000221801 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | 0.582 |
| GNL2 | GTPBP4 | ENSP00000362153 | ENSP00000354040 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | GTP binding protein 4; Involved in the biogenesis of the 60S ribosomal subunit (By similarity) | 0.999 |
| GNL2 | PRMT1 | ENSP00000362153 | ENSP00000406162 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | protein arginine methyltransferase 1 | 0.778 |
| GNL2 | PRMT8 | ENSP00000362153 | ENSP00000372067 | guanine nucleotide binding protein-like 2 (nucleolar); GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity) | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | 0.778 |
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