node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAH | FAHD1 | ENSP00000261755 | ENSP00000372112 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | 0.920 |
FAH | FH | ENSP00000261755 | ENSP00000355518 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | fumarate hydratase; Also acts as a tumor suppressor | 0.836 |
FAH | HGD | ENSP00000261755 | ENSP00000283871 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | homogentisate 1,2-dioxygenase | 0.896 |
FAH | PCNA | ENSP00000261755 | ENSP00000368438 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.426 |
FAH | SDHA | ENSP00000261755 | ENSP00000264932 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | 0.811 |
FAH | SDHB | ENSP00000261755 | ENSP00000364649 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.806 |
FAH | SDHC | ENSP00000261755 | ENSP00000356953 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.805 |
FAH | SDHD | ENSP00000261755 | ENSP00000364699 | fumarylacetoacetate hydrolase (fumarylacetoacetase) | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) | 0.800 |
FAHD1 | FAH | ENSP00000372112 | ENSP00000261755 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.920 |
FAHD1 | FH | ENSP00000372112 | ENSP00000355518 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | fumarate hydratase; Also acts as a tumor suppressor | 0.800 |
FAHD1 | GNPTG | ENSP00000372112 | ENSP00000204679 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | N-acetylglucosamine-1-phosphate transferase, gamma subunit; May recognize the substrate of GlcNAc-1- phosphotransferase but also the lysosomal proteins with mannose-6- phosphate residues | 0.642 |
FAHD1 | HGD | ENSP00000372112 | ENSP00000283871 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | homogentisate 1,2-dioxygenase | 0.594 |
FAHD1 | PCNA | ENSP00000372112 | ENSP00000368438 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...] | 0.961 |
FAHD1 | RAD1 | ENSP00000372112 | ENSP00000340879 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | RAD1 homolog (S. pombe); Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3’-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity [...] | 0.960 |
FAHD1 | SDHA | ENSP00000372112 | ENSP00000264932 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | 0.811 |
FAHD1 | SDHB | ENSP00000372112 | ENSP00000364649 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.806 |
FAHD1 | SDHC | ENSP00000372112 | ENSP00000356953 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.807 |
FAHD1 | SDHD | ENSP00000372112 | ENSP00000364699 | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) | 0.814 |
FH | FAH | ENSP00000355518 | ENSP00000261755 | fumarate hydratase; Also acts as a tumor suppressor | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 0.836 |
FH | FAHD1 | ENSP00000355518 | ENSP00000372112 | fumarate hydratase; Also acts as a tumor suppressor | fumarylacetoacetate hydrolase domain containing 1; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro | 0.800 |