Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | N6AMT2 | N-6 adenine-specific DNA methyltransferase 2 (putative); Putative DNA methyltransferase (By similarity) (214 aa) | ||||||||||||
Predicted Functional Partners:
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 | THAP6 | THAP domain containing 6 (222 aa) |
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0.789 | ||||||||||
 | PATE3 | prostate and testis expressed 3 (98 aa) |
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0.754 | ||||||||||
 | SPINK13 | serine peptidase inhibitor, Kazal type 13 (putative); May be a serine protease inhibitor (By similarity) (94 aa) |
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0.725 | ||||||||||
 | DEFB132 | defensin, beta 132; Has antibacterial activity (Potential) (95 aa) |
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0.725 | ||||||||||
 | CLPSL1 | colipase-like 1 (121 aa) |
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0.708 | ||||||||||
 | RPL7L1 | ribosomal protein L7-like 1 (246 aa) |
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0.682 | ||||||||||
 | PLEKHH3 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 3 (793 aa) |
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0.657 | ||||||||||
 | HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) (346 aa) |
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0.557 | ||||||||||
 | N6AMT1 | N-6 adenine-specific DNA methyltransferase 1 (putative); Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on ’Gln-185’, using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (214 aa) |
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0.514 | ||||||||||
 | ZNF274 | zinc finger protein 274; Probable transcription repressor. Specifically binds to the 3’-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (652 aa) |
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0.454 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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