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STRINGSTRING
ZBTB43 ZBTB43 RNMTL1 RNMTL1 MUC16 MUC16 LAMTOR3 LAMTOR3 RALA RALA MSLN MSLN WFDC2 WFDC2 MPV17 MPV17 NDUFB5 NDUFB5 WNT5A WNT5A NDUFB9 NDUFB9
"MSLN" - mesothelin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
MSLNmesothelin (630 aa)    
Predicted Functional Partners:
MUC16
mucin 16, cell surface associated; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity) (14507 aa)
        score_image   score_image   0.977
NDUFB5
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (189 aa)
        score_image       0.948
ZBTB43
zinc finger and BTB domain containing 43; May be involved in transcriptional regulation (467 aa)
        score_image       0.934
RALA
v-ral simian leukemia viral oncogene homolog A (ras related); Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin- dependent membrane raft exocyt [...] (206 aa)
        score_image   score_image   0.914
NDUFB9
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (179 aa)
        score_image       0.906
RNMTL1
RNA methyltransferase like 1; Probable RNA methyltransferase (By similarity) (420 aa)
        score_image       0.902
LAMTOR3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances th [...] (124 aa)
        score_image   score_image   0.897
WNT5A
wingless-type MMTV integration site family, member 5A; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates [...] (380 aa)
            score_image   0.836
WFDC2
WAP four-disulfide core domain 2 (124 aa)
            score_image   0.720
MPV17
MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (176 aa)
        score_image       0.655
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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