| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COX10 | FECH | ENSP00000261643 | ENSP00000372326 | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | 0.939 |
| COX10 | HCCS | ENSP00000261643 | ENSP00000326579 | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | holocytochrome c synthase; Links covalently the heme group to the apoprotein of cytochrome c (By similarity) | 0.932 |
| CP | FECH | ENSP00000264613 | ENSP00000372326 | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | 0.922 |
| CP | FTH1 | ENSP00000264613 | ENSP00000273550 | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.513 |
| CP | FTL | ENSP00000264613 | ENSP00000366525 | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | 0.507 |
| CP | FXN | ENSP00000264613 | ENSP00000366482 | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.711 |
| FECH | COX10 | ENSP00000372326 | ENSP00000261643 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | cytochrome c oxidase assembly homolog 10 (yeast); Converts protoheme IX and farnesyl diphosphate to heme O (By similarity) | 0.939 |
| FECH | CP | ENSP00000372326 | ENSP00000264613 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | 0.922 |
| FECH | FTH1 | ENSP00000372326 | ENSP00000273550 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | 0.933 |
| FECH | FTL | ENSP00000372326 | ENSP00000366525 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | 0.923 |
| FECH | FTMT | ENSP00000372326 | ENSP00000313691 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | ferritin mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation | 0.944 |
| FECH | FXN | ENSP00000372326 | ENSP00000366482 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.924 |
| FECH | HCCS | ENSP00000372326 | ENSP00000326579 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | holocytochrome c synthase; Links covalently the heme group to the apoprotein of cytochrome c (By similarity) | 0.941 |
| FECH | PPOX | ENSP00000372326 | ENSP00000343943 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | 0.995 |
| FECH | SLC25A37 | ENSP00000372326 | ENSP00000429200 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity) | 0.908 |
| FECH | UROD | ENSP00000372326 | ENSP00000246337 | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III | 0.950 |
| FTH1 | CP | ENSP00000273550 | ENSP00000264613 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | ceruloplasmin (ferroxidase); Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity) | 0.513 |
| FTH1 | FECH | ENSP00000273550 | ENSP00000372326 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) | 0.933 |
| FTH1 | FTL | ENSP00000273550 | ENSP00000366525 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | ferritin, light polypeptide; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity) | 0.999 |
| FTH1 | PPOX | ENSP00000273550 | ENSP00000343943 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX | 0.581 |
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