node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ESCO1 | NIPBL | ENSP00000269214 | ENSP00000282516 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | 0.806 |
ESCO1 | PDS5A | ENSP00000269214 | ENSP00000303427 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair | 0.997 |
ESCO1 | PDS5B | ENSP00000269214 | ENSP00000313851 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells | 0.991 |
ESCO1 | RAD21 | ENSP00000269214 | ENSP00000297338 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.992 |
ESCO1 | SMC1B | ENSP00000269214 | ENSP00000350036 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | 0.744 |
ESCO1 | SMC3 | ENSP00000269214 | ENSP00000354720 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | structural maintenance of chromosomes 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement | 0.999 |
ESCO1 | STAG1 | ENSP00000269214 | ENSP00000372689 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | stromal antigen 1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.985 |
ESCO1 | STAG2 | ENSP00000269214 | ENSP00000218089 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | stromal antigen 2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.980 |
ESCO1 | WAPAL | ENSP00000269214 | ENSP00000298767 | establishment of cohesion 1 homolog 1 (S. cerevisiae) | wings apart-like homolog (Drosophila); Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair | 0.982 |
ESCO2 | NIPBL | ENSP00000306999 | ENSP00000282516 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | 0.819 |
ESCO2 | PDS5A | ENSP00000306999 | ENSP00000303427 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae); Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair | 0.997 |
ESCO2 | PDS5B | ENSP00000306999 | ENSP00000313851 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae); Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells | 0.990 |
ESCO2 | RAD21 | ENSP00000306999 | ENSP00000297338 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | RAD21 homolog (S. pombe); Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Als [...] | 0.991 |
ESCO2 | SMC1B | ENSP00000306999 | ENSP00000350036 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | structural maintenance of chromosomes 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the compl [...] | 0.744 |
ESCO2 | SMC3 | ENSP00000306999 | ENSP00000354720 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | structural maintenance of chromosomes 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement | 0.999 |
ESCO2 | STAG1 | ENSP00000306999 | ENSP00000372689 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | stromal antigen 1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.983 |
ESCO2 | STAG2 | ENSP00000306999 | ENSP00000218089 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | stromal antigen 2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis | 0.980 |
ESCO2 | WAPAL | ENSP00000306999 | ENSP00000298767 | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | wings apart-like homolog (Drosophila); Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister- chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair | 0.982 |
NIPBL | ESCO1 | ENSP00000282516 | ENSP00000269214 | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | establishment of cohesion 1 homolog 1 (S. cerevisiae) | 0.806 |
NIPBL | ESCO2 | ENSP00000282516 | ENSP00000306999 | Nipped-B homolog (Drosophila); Probably plays a structural role in chromatin. Involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity) | establishment of cohesion 1 homolog 2 (S. cerevisiae); Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 | 0.819 |