| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALG5 | PTPLB | ENSP00000239891 | ENSP00000373153 | asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.667 |
| ALG5 | UBC | ENSP00000239891 | ENSP00000344818 | asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) | ubiquitin C | 0.799 |
| BCAP31 | PTPLB | ENSP00000392330 | ENSP00000373153 | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.576 |
| FXR1 | PTPLB | ENSP00000350170 | ENSP00000373153 | fragile X mental retardation, autosomal homolog 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity) | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.534 |
| FXR1 | UBC | ENSP00000350170 | ENSP00000344818 | fragile X mental retardation, autosomal homolog 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity) | ubiquitin C | 0.907 |
| HSD17B12 | PTPLB | ENSP00000278353 | ENSP00000373153 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.965 |
| HSD17B12 | TECR | ENSP00000278353 | ENSP00000215567 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids | 0.836 |
| HSD17B12 | TECRL | ENSP00000278353 | ENSP00000370607 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | trans-2,3-enoyl-CoA reductase-like | 0.682 |
| HSD17B12 | UBC | ENSP00000278353 | ENSP00000344818 | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | ubiquitin C | 0.937 |
| LPIN1 | PTPLB | ENSP00000256720 | ENSP00000373153 | lipin 1; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosp [...] | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.827 |
| PIGL | PTPLB | ENSP00000225609 | ENSP00000373153 | phosphatidylinositol glycan anchor biosynthesis, class L; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | 0.566 |
| PTPLB | ALG5 | ENSP00000373153 | ENSP00000239891 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | asparagine-linked glycosylation 5, dolichyl-phosphate beta-glucosyltransferase homolog (S. cerevisiae) | 0.667 |
| PTPLB | BCAP31 | ENSP00000373153 | ENSP00000392330 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | B-cell receptor-associated protein 31; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis | 0.576 |
| PTPLB | FXR1 | ENSP00000373153 | ENSP00000350170 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | fragile X mental retardation, autosomal homolog 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs (By similarity) | 0.534 |
| PTPLB | HSD17B12 | ENSP00000373153 | ENSP00000278353 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | hydroxysteroid (17-beta) dehydrogenase 12; Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation | 0.965 |
| PTPLB | LPIN1 | ENSP00000373153 | ENSP00000256720 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | lipin 1; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosp [...] | 0.827 |
| PTPLB | PIGL | ENSP00000373153 | ENSP00000225609 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | phosphatidylinositol glycan anchor biosynthesis, class L; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol | 0.566 |
| PTPLB | TECR | ENSP00000373153 | ENSP00000215567 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | trans-2,3-enoyl-CoA reductase; Reduces trans-2,3-stearoyl-CoA to stearoyl-CoA of long and very long chain fatty acids | 0.988 |
| PTPLB | TECRL | ENSP00000373153 | ENSP00000370607 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | trans-2,3-enoyl-CoA reductase-like | 0.663 |
| PTPLB | UBC | ENSP00000373153 | ENSP00000344818 | protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis | ubiquitin C | 0.620 |
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