node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACHE | AGRN | ENSP00000303211 | ENSP00000368678 | acetylcholinesterase | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | 0.649 |
ACHE | COLQ | ENSP00000303211 | ENSP00000373298 | acetylcholinesterase | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.963 |
ACHE | DOK7 | ENSP00000303211 | ENSP00000344432 | acetylcholinesterase | docking protein 7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK | 0.662 |
ACHE | DPAGT1 | ENSP00000303211 | ENSP00000346142 | acetylcholinesterase | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | 0.607 |
ACHE | MUSK | ENSP00000303211 | ENSP00000363571 | acetylcholinesterase | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | 0.659 |
ACHE | PRIMA1 | ENSP00000303211 | ENSP00000376848 | acetylcholinesterase | proline rich membrane anchor 1; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity) | 0.792 |
AGRN | ACHE | ENSP00000368678 | ENSP00000303211 | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | acetylcholinesterase | 0.649 |
AGRN | COLQ | ENSP00000368678 | ENSP00000373298 | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.681 |
AGRN | DOK7 | ENSP00000368678 | ENSP00000344432 | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | docking protein 7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK | 0.762 |
AGRN | DPAGT1 | ENSP00000368678 | ENSP00000346142 | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | 0.749 |
AGRN | MUSK | ENSP00000368678 | ENSP00000363571 | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | muscle, skeletal, receptor tyrosine kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton an [...] | 0.993 |
BCHE | COLQ | ENSP00000264381 | ENSP00000373298 | butyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | 0.891 |
BCHE | PRIMA1 | ENSP00000264381 | ENSP00000376848 | butyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters | proline rich membrane anchor 1; Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers (By similarity) | 0.502 |
COLQ | ACHE | ENSP00000373298 | ENSP00000303211 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | acetylcholinesterase | 0.963 |
COLQ | AGRN | ENSP00000373298 | ENSP00000368678 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | agrin; Agrin N-terminal 110 kDa subunit- is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity) | 0.681 |
COLQ | BCHE | ENSP00000373298 | ENSP00000264381 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | butyrylcholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters | 0.891 |
COLQ | DHX8 | ENSP00000373298 | ENSP00000262415 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | DEAH (Asp-Glu-Ala-His) box polypeptide 8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome | 0.740 |
COLQ | DOK7 | ENSP00000373298 | ENSP00000344432 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | docking protein 7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK | 0.660 |
COLQ | DPAGT1 | ENSP00000373298 | ENSP00000346142 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase); Catalyzes the initial step in the synthesis of dolichol- P-P-oligosaccharides | 0.610 |
COLQ | KCNH2 | ENSP00000373298 | ENSP00000262186 | collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.619 |