RPUSD3 protein (Homo sapiens) - STRING network view

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RPUSD3

RNA pseudouridylate synthase domain containing 3 (351 aa)

Predicted Functional Partners:

RPUSD2

0.725

RPUSD1

0.719

TRUB2

0.704

THUMPD3

0.628

QTRTD1

0.610

THG1L

0.567

MORN5

0.563

TRIT1

0.543

LOXL2

0.483

GMPS

0.481

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GMPS	RPUSD1	ENSP00000419851	ENSP00000007264	guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division	RNA pseudouridylate synthase domain containing 1	0.481
GMPS	RPUSD2	ENSP00000419851	ENSP00000323288	guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division	RNA pseudouridylate synthase domain containing 2	0.481
GMPS	RPUSD3	ENSP00000419851	ENSP00000373331	guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division	RNA pseudouridylate synthase domain containing 3	0.481
GMPS	TRIT1	ENSP00000419851	ENSP00000321810	guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division	tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	0.586
LOXL2	RPUSD3	ENSP00000373783	ENSP00000373331	lysyl oxidase-like 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated ’Lys-4’ of histone H3 (H3 [...]	RNA pseudouridylate synthase domain containing 3	0.483
MORN5	RPUSD3	ENSP00000362869	ENSP00000373331	MORN repeat containing 5	RNA pseudouridylate synthase domain containing 3	0.563
QTRTD1	RPUSD1	ENSP00000281273	ENSP00000007264	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	RNA pseudouridylate synthase domain containing 1	0.542
QTRTD1	RPUSD2	ENSP00000281273	ENSP00000323288	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	RNA pseudouridylate synthase domain containing 2	0.601
QTRTD1	RPUSD3	ENSP00000281273	ENSP00000373331	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	RNA pseudouridylate synthase domain containing 3	0.610
QTRTD1	THG1L	ENSP00000281273	ENSP00000231198	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae); Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis	0.619
QTRTD1	THUMPD3	ENSP00000281273	ENSP00000339532	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	THUMP domain containing 3	0.701
QTRTD1	TRIT1	ENSP00000281273	ENSP00000321810	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	0.615
QTRTD1	TRUB2	ENSP00000281273	ENSP00000361982	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	TruB pseudouridine (psi) synthase homolog 2 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)	0.618
RPUSD1	GMPS	ENSP00000007264	ENSP00000419851	RNA pseudouridylate synthase domain containing 1	guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division	0.481
RPUSD1	QTRTD1	ENSP00000007264	ENSP00000281273	RNA pseudouridylate synthase domain containing 1	queuine tRNA-ribosyltransferase domain containing 1; Interacts with QTRT1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine) (By similarity)	0.542
RPUSD1	RPUSD3	ENSP00000007264	ENSP00000373331	RNA pseudouridylate synthase domain containing 1	RNA pseudouridylate synthase domain containing 3	0.719
RPUSD1	THG1L	ENSP00000007264	ENSP00000231198	RNA pseudouridylate synthase domain containing 1	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae); Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis	0.518
RPUSD1	THUMPD3	ENSP00000007264	ENSP00000339532	RNA pseudouridylate synthase domain containing 1	THUMP domain containing 3	0.566
RPUSD1	TRIT1	ENSP00000007264	ENSP00000321810	RNA pseudouridylate synthase domain containing 1	tRNA isopentenyltransferase 1; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	0.510
RPUSD1	TRUB2	ENSP00000007264	ENSP00000361982	RNA pseudouridylate synthase domain containing 1	TruB pseudouridine (psi) synthase homolog 2 (E. coli); May be responsible for synthesis of pseudouridine from uracil in transfer RNAs (By similarity)	0.745

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