UFSP1 protein (Homo sapiens) - STRING network view

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UFSP1

UFM1-specific peptidase 1 (non-functional) (142 aa)

Predicted Functional Partners:

UFM1

0.977

DDRGK1

0.775

UFL1

0.770

UBA5

0.748

UFC1

0.726

SLC12A9

0.579

URM1

0.518

ALKBH1

0.410

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH1	UFSP1	ENSP00000216489	ENSP00000373413	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	UFM1-specific peptidase 1 (non-functional)	0.410
DDRGK1	UBA5	ENSP00000346483	ENSP00000348565	DDRGK domain containing 1	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	0.729
DDRGK1	UFC1	ENSP00000346483	ENSP00000356982	DDRGK domain containing 1	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.722
DDRGK1	UFL1	ENSP00000346483	ENSP00000358283	DDRGK domain containing 1	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.990
DDRGK1	UFM1	ENSP00000346483	ENSP00000239878	DDRGK domain containing 1	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.952
DDRGK1	UFSP1	ENSP00000346483	ENSP00000373413	DDRGK domain containing 1	UFM1-specific peptidase 1 (non-functional)	0.775
DDRGK1	URM1	ENSP00000346483	ENSP00000412922	DDRGK domain containing 1	ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo	0.684
SLC12A9	UFSP1	ENSP00000275730	ENSP00000373413	solute carrier family 12 (potassium/chloride transporters), member 9	UFM1-specific peptidase 1 (non-functional)	0.579
UBA5	DDRGK1	ENSP00000348565	ENSP00000346483	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	DDRGK domain containing 1	0.729
UBA5	UFC1	ENSP00000348565	ENSP00000356982	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.934
UBA5	UFL1	ENSP00000348565	ENSP00000358283	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.795
UBA5	UFM1	ENSP00000348565	ENSP00000239878	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.993
UBA5	UFSP1	ENSP00000348565	ENSP00000373413	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	UFM1-specific peptidase 1 (non-functional)	0.748
UBA5	URM1	ENSP00000348565	ENSP00000412922	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo	0.758
UFC1	DDRGK1	ENSP00000356982	ENSP00000346483	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	DDRGK domain containing 1	0.722
UFC1	UBA5	ENSP00000356982	ENSP00000348565	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	0.934
UFC1	UFL1	ENSP00000356982	ENSP00000358283	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.953
UFC1	UFM1	ENSP00000356982	ENSP00000239878	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.999
UFC1	UFSP1	ENSP00000356982	ENSP00000373413	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	UFM1-specific peptidase 1 (non-functional)	0.726
UFL1	DDRGK1	ENSP00000358283	ENSP00000346483	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	DDRGK domain containing 1	0.990

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