METTL14 protein (Homo sapiens) - STRING network view

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Score

METTL14

methyltransferase like 14; Probable methyltransferase (By similarity) (456 aa)

Predicted Functional Partners:

WTAP

0.989

METTL3

0.989

METTL4

0.910

RQCD1

0.846

SH3BP5

0.656

SNF8

0.644

SNX15

0.644

UBC

0.620

P5CR2

0.564

PYCR2

0.542

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
METTL14	METTL3	ENSP00000373474	ENSP00000298717	methyltransferase like 14; Probable methyltransferase (By similarity)	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	0.989
METTL14	METTL4	ENSP00000373474	ENSP00000458290	methyltransferase like 14; Probable methyltransferase (By similarity)	methyltransferase like 4; Probable methyltransferase (By similarity)	0.910
METTL14	P5CR2	ENSP00000373474	ENSP00000414068	methyltransferase like 14; Probable methyltransferase (By similarity)	Uncharacterized protein	0.564
METTL14	PYCR2	ENSP00000373474	ENSP00000342502	methyltransferase like 14; Probable methyltransferase (By similarity)	pyrroline-5-carboxylate reductase family, member 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH	0.542
METTL14	RQCD1	ENSP00000373474	ENSP00000273064	methyltransferase like 14; Probable methyltransferase (By similarity)	RCD1 required for cell differentiation1 homolog (S. pombe); Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such a [...]	0.846
METTL14	SH3BP5	ENSP00000373474	ENSP00000373301	methyltransferase like 14; Probable methyltransferase (By similarity)	SH3-domain binding protein 5 (BTK-associated); Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death	0.656
METTL14	SNF8	ENSP00000373474	ENSP00000421380	methyltransferase like 14; Probable methyltransferase (By similarity)	SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly [...]	0.644
METTL14	SNX15	ENSP00000373474	ENSP00000366452	methyltransferase like 14; Probable methyltransferase (By similarity)	sorting nexin 15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN	0.644
METTL14	UBC	ENSP00000373474	ENSP00000344818	methyltransferase like 14; Probable methyltransferase (By similarity)	ubiquitin C	0.620
METTL14	WTAP	ENSP00000373474	ENSP00000351141	methyltransferase like 14; Probable methyltransferase (By similarity)	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.989
METTL3	METTL14	ENSP00000298717	ENSP00000373474	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	methyltransferase like 14; Probable methyltransferase (By similarity)	0.989
METTL3	METTL4	ENSP00000298717	ENSP00000458290	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	methyltransferase like 4; Probable methyltransferase (By similarity)	0.910
METTL3	UBC	ENSP00000298717	ENSP00000344818	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	ubiquitin C	0.483
METTL3	WTAP	ENSP00000298717	ENSP00000351141	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	Wilms tumor 1 associated protein; Regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. Impairs WT1 DNA- binding ability and inhibits expression of WT1 target genes. May be involved in mRNA splicing regulation	0.989
METTL4	METTL14	ENSP00000458290	ENSP00000373474	methyltransferase like 4; Probable methyltransferase (By similarity)	methyltransferase like 14; Probable methyltransferase (By similarity)	0.910
METTL4	METTL3	ENSP00000458290	ENSP00000298717	methyltransferase like 4; Probable methyltransferase (By similarity)	methyltransferase like 3; N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation	0.910
P5CR2	METTL14	ENSP00000414068	ENSP00000373474	Uncharacterized protein	methyltransferase like 14; Probable methyltransferase (By similarity)	0.564
PYCR2	METTL14	ENSP00000342502	ENSP00000373474	pyrroline-5-carboxylate reductase family, member 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH	methyltransferase like 14; Probable methyltransferase (By similarity)	0.542
PYCR2	UBC	ENSP00000342502	ENSP00000344818	pyrroline-5-carboxylate reductase family, member 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH	ubiquitin C	0.838
RQCD1	METTL14	ENSP00000273064	ENSP00000373474	RCD1 required for cell differentiation1 homolog (S. pombe); Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such a [...]	methyltransferase like 14; Probable methyltransferase (By similarity)	0.846

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