node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KCNAB1 | KCNH1 | ENSP00000419952 | ENSP00000271751 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | 0.924 |
KCNAB1 | KCNH2 | ENSP00000419952 | ENSP00000262186 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.942 |
KCNAB1 | KCNH3 | ENSP00000419952 | ENSP00000257981 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly | 0.919 |
KCNAB1 | KCNH5 | ENSP00000419952 | ENSP00000321427 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.920 |
KCNAB1 | KCNH6 | ENSP00000419952 | ENSP00000463533 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly | 0.932 |
KCNAB1 | KCNH8 | ENSP00000419952 | ENSP00000328813 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, subfamily H (eag-related), member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.927 |
KCNAB1 | KCNQ2 | ENSP00000419952 | ENSP00000352035 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 2 | 0.940 |
KCNAB1 | KCNQ3 | ENSP00000419952 | ENSP00000373648 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs | 0.939 |
KCNAB1 | KCNQ4 | ENSP00000419952 | ENSP00000262916 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors | 0.919 |
KCNAB1 | KCNQ5 | ENSP00000419952 | ENSP00000345055 | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | potassium voltage-gated channel, KQT-like subfamily, member 5 | 0.920 |
KCNH1 | KCNAB1 | ENSP00000271751 | ENSP00000419952 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, shaker-related subfamily, beta member 1 | 0.924 |
KCNH1 | KCNH2 | ENSP00000271751 | ENSP00000262186 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | 0.914 |
KCNH1 | KCNH3 | ENSP00000271751 | ENSP00000257981 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, subfamily H (eag-related), member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly | 0.915 |
KCNH1 | KCNH5 | ENSP00000271751 | ENSP00000321427 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, subfamily H (eag-related), member 5; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a non-inactivating outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.956 |
KCNH1 | KCNH6 | ENSP00000271751 | ENSP00000463533 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, subfamily H (eag-related), member 6; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly | 0.907 |
KCNH1 | KCNH8 | ENSP00000271751 | ENSP00000328813 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, subfamily H (eag-related), member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly | 0.913 |
KCNH1 | KCNQ2 | ENSP00000271751 | ENSP00000352035 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, KQT-like subfamily, member 2 | 0.959 |
KCNH1 | KCNQ3 | ENSP00000271751 | ENSP00000373648 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, KQT-like subfamily, member 3; Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs | 0.959 |
KCNH1 | KCNQ4 | ENSP00000271751 | ENSP00000262916 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, KQT-like subfamily, member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors | 0.950 |
KCNH1 | KCNQ5 | ENSP00000271751 | ENSP00000345055 | potassium voltage-gated channel, subfamily H (eag-related), member 1; Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates IK(NI) current in myoblasts | potassium voltage-gated channel, KQT-like subfamily, member 5 | 0.944 |