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INPP5E INPP5E PI4KB PI4KB PI4KA PI4KA PIKFYVE PIKFYVE VAC14 VAC14 OCRL OCRL UBC UBC SACM1L SACM1L GOLPH3L GOLPH3L GOLPH3 GOLPH3 TPTE2 TPTE2
"SACM1L" - SAC1 suppressor of actin mutations 1-like in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Known Interactions
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Predicted Interactions
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Score
SACM1LSAC1 suppressor of actin mutations 1-like (yeast); Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2 (By similarity) (587 aa)    
Predicted Functional Partners:
PI4KA
phosphatidylinositol 4-kinase, catalytic, alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (2044 aa)
        score_image score_image score_image   0.997
OCRL
oculocerebrorenal syndrome of Lowe (901 aa)
  score_image     score_image score_image score_image   0.980
PIKFYVE
phosphoinositide kinase, FYVE finger containing; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes (2098 aa)
        score_image score_image score_image   0.969
PI4KB
phosphatidylinositol 4-kinase, catalytic, beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (828 aa)
      score_image score_image score_image score_image   0.967
VAC14
Vac14 homolog (S. cerevisiae); The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes (782 aa)
        score_image score_image score_image   0.963
INPP5E
inositol polyphosphate-5-phosphatase, 72 kDa; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates (644 aa)
  score_image     score_image score_image score_image   0.960
GOLPH3
golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene (298 aa)
        score_image   score_image   0.950
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.930
GOLPH3L
golgi phosphoprotein 3-like (285 aa)
        score_image   score_image   0.929
TPTE2
transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 (522 aa)
        score_image score_image score_image   0.926
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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