node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNOT4 | LTN1 | ENSP00000445508 | ENSP00000373846 | CCR4-NOT transcription complex, subunit 4 | listerin E3 ubiquitin protein ligase 1 | 0.855 |
CNOT4 | UBA1 | ENSP00000445508 | ENSP00000338413 | CCR4-NOT transcription complex, subunit 4 | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.402 |
CNOT4 | UBC | ENSP00000445508 | ENSP00000344818 | CCR4-NOT transcription complex, subunit 4 | ubiquitin C | 0.811 |
CNOT4 | UBE2D2 | ENSP00000445508 | ENSP00000381717 | CCR4-NOT transcription complex, subunit 4 | ubiquitin-conjugating enzyme E2D 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’-, as well as ’Lys-48’-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ’Lys-21’ and/or ’Lys-22’ with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-prime [...] | 0.999 |
DNAJC2 | LTN1 | ENSP00000368565 | ENSP00000373846 | DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] | listerin E3 ubiquitin protein ligase 1 | 0.810 |
DNAJC2 | UBC | ENSP00000368565 | ENSP00000344818 | DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] | ubiquitin C | 0.737 |
ERMN | LTN1 | ENSP00000380453 | ENSP00000373846 | ermin, ERM-like protein; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity) | listerin E3 ubiquitin protein ligase 1 | 0.582 |
HBS1L | LTN1 | ENSP00000356811 | ENSP00000373846 | HBS1-like (S. cerevisiae) | listerin E3 ubiquitin protein ligase 1 | 0.584 |
HBS1L | UBC | ENSP00000356811 | ENSP00000344818 | HBS1-like (S. cerevisiae) | ubiquitin C | 0.945 |
LTN1 | CNOT4 | ENSP00000373846 | ENSP00000445508 | listerin E3 ubiquitin protein ligase 1 | CCR4-NOT transcription complex, subunit 4 | 0.855 |
LTN1 | DNAJC2 | ENSP00000373846 | ENSP00000368565 | listerin E3 ubiquitin protein ligase 1 | DnaJ (Hsp40) homolog, subfamily C, member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone- component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state- specifically recruit [...] | 0.810 |
LTN1 | ERMN | ENSP00000373846 | ENSP00000380453 | listerin E3 ubiquitin protein ligase 1 | ermin, ERM-like protein; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity) | 0.582 |
LTN1 | HBS1L | ENSP00000373846 | ENSP00000356811 | listerin E3 ubiquitin protein ligase 1 | HBS1-like (S. cerevisiae) | 0.584 |
LTN1 | NEMF | ENSP00000373846 | ENSP00000298310 | listerin E3 ubiquitin protein ligase 1 | nuclear export mediator factor | 0.693 |
LTN1 | RTF1 | ENSP00000373846 | ENSP00000374280 | listerin E3 ubiquitin protein ligase 1 | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae); Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and ’Ser-2’- and ’Ser-5’-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is r [...] | 0.737 |
LTN1 | UBA1 | ENSP00000373846 | ENSP00000338413 | listerin E3 ubiquitin protein ligase 1 | ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP | 0.620 |
LTN1 | UBC | ENSP00000373846 | ENSP00000344818 | listerin E3 ubiquitin protein ligase 1 | ubiquitin C | 0.881 |
LTN1 | UBE2A | ENSP00000373846 | ENSP00000360613 | listerin E3 ubiquitin protein ligase 1 | ubiquitin-conjugating enzyme E2A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at ’Lys-120’ to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes ’Lys-11’, as well as ’Lys-48’-linked polyubiquitination. Require [...] | 0.813 |
LTN1 | UBE2D2 | ENSP00000373846 | ENSP00000381717 | listerin E3 ubiquitin protein ligase 1 | ubiquitin-conjugating enzyme E2D 2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes ’Lys- 11’-, as well as ’Lys-48’-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions ’Lys-21’ and/or ’Lys-22’ with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-prime [...] | 0.727 |
NEMF | LTN1 | ENSP00000298310 | ENSP00000373846 | nuclear export mediator factor | listerin E3 ubiquitin protein ligase 1 | 0.693 |