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GPHN GPHN UBA1 UBA1 GARS GARS IARS IARS QARS QARS EPRS EPRS RARS RARS AARS AARS ASNS ASNS DARS DARS NARS NARS
"GARS" - glycyl-tRNA synthetase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
GARSglycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Is also able produce diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs (739 aa)    
Predicted Functional Partners:
IARS
isoleucyl-tRNA synthetase (1262 aa)
     score_image score_image score_image   score_image   0.998
AARS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) (968 aa)
       score_image score_image   score_image   0.998
NARS
asparaginyl-tRNA synthetase (548 aa)
       score_image score_image   score_image   0.995
QARS
glutaminyl-tRNA synthetase (775 aa)
 score_image     score_image score_image   score_image   0.993
EPRS
glutamyl-prolyl-tRNA synthetase (1512 aa)
 score_image     score_image score_image   score_image   0.993
RARS
arginyl-tRNA synthetase; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1 (660 aa)
       score_image score_image   score_image   0.989
ASNS
asparagine synthetase (glutamine-hydrolyzing) (561 aa)
       score_image score_image   score_image   0.989
DARS
aspartyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (501 aa)
       score_image score_image   score_image   0.983
GPHN
gephyrin; Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released (769 aa)
             score_image   0.973
UBA1
ubiquitin-like modifier activating enzyme 1; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP (1058 aa)
       score_image score_image       0.956
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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