node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DNAJB11 | PRTG | ENSP00000265028 | ENSP00000373937 | DnaJ (Hsp40) homolog, subfamily B, member 11; Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity | protogenin; May play a role in anteroposterior axis elongation (By similarity) | 0.834 |
EVX1 | PRTG | ENSP00000419266 | ENSP00000373937 | even-skipped homeobox 1; May play a role in the specification of neuronal cell types | protogenin; May play a role in anteroposterior axis elongation (By similarity) | 0.667 |
IQSEC1 | NTN1 | ENSP00000273221 | ENSP00000173229 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.631 |
IQSEC1 | NTN3 | ENSP00000273221 | ENSP00000293973 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.624 |
IQSEC1 | NTN5 | ENSP00000273221 | ENSP00000270235 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin 5 | 0.602 |
IQSEC1 | NTNG1 | ENSP00000273221 | ENSP00000359085 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.607 |
IQSEC1 | NTNG2 | ENSP00000273221 | ENSP00000376921 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.602 |
IQSEC1 | PRTG | ENSP00000273221 | ENSP00000373937 | IQ motif and Sec7 domain 1; In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin | protogenin; May play a role in anteroposterior axis elongation (By similarity) | 0.691 |
IQSEC2 | NTN1 | ENSP00000379712 | ENSP00000173229 | IQ motif and Sec7 domain 2 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.624 |
IQSEC2 | NTN3 | ENSP00000379712 | ENSP00000293973 | IQ motif and Sec7 domain 2 | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.624 |
IQSEC2 | NTN5 | ENSP00000379712 | ENSP00000270235 | IQ motif and Sec7 domain 2 | netrin 5 | 0.602 |
IQSEC2 | NTNG1 | ENSP00000379712 | ENSP00000359085 | IQ motif and Sec7 domain 2 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.607 |
IQSEC2 | NTNG2 | ENSP00000379712 | ENSP00000376921 | IQ motif and Sec7 domain 2 | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.602 |
IQSEC2 | PRTG | ENSP00000379712 | ENSP00000373937 | IQ motif and Sec7 domain 2 | protogenin; May play a role in anteroposterior axis elongation (By similarity) | 0.691 |
IQSEC3 | NTN1 | ENSP00000315662 | ENSP00000173229 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | netrin 1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis | 0.624 |
IQSEC3 | NTN3 | ENSP00000315662 | ENSP00000293973 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | netrin 3; Netrins control guidance of CNS commissural axons and peripheral motor axons (By similarity) | 0.624 |
IQSEC3 | NTN5 | ENSP00000315662 | ENSP00000270235 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | netrin 5 | 0.602 |
IQSEC3 | NTNG1 | ENSP00000315662 | ENSP00000359085 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | netrin G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.607 |
IQSEC3 | NTNG2 | ENSP00000315662 | ENSP00000376921 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | netrin G2; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites | 0.602 |
IQSEC3 | PRTG | ENSP00000315662 | ENSP00000373937 | IQ motif and Sec7 domain 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1 | protogenin; May play a role in anteroposterior axis elongation (By similarity) | 0.691 |