node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS20 | ENSP00000387356 | ENSP00000374071 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.407 |
ACAN | FURIN | ENSP00000387356 | ENSP00000268171 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | 0.472 |
ACAN | VCAN | ENSP00000387356 | ENSP00000265077 | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid | 0.969 |
ADAMTS20 | ACAN | ENSP00000374071 | ENSP00000387356 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.407 |
ADAMTS20 | CD36 | ENSP00000374071 | ENSP00000308165 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | CD36 molecule (thrombospondin receptor) | 0.610 |
ADAMTS20 | FURIN | ENSP00000374071 | ENSP00000268171 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | 0.561 |
ADAMTS20 | KCTD9 | ENSP00000374071 | ENSP00000221200 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | potassium channel tetramerisation domain containing 9 | 0.416 |
ADAMTS20 | OCA2 | ENSP00000374071 | ENSP00000346659 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.403 |
ADAMTS20 | SLC24A5 | ENSP00000374071 | ENSP00000341550 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.487 |
ADAMTS20 | TSR3 | ENSP00000374071 | ENSP00000007390 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity) | 0.475 |
ADAMTS20 | VCAN | ENSP00000374071 | ENSP00000265077 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid | 0.454 |
CD36 | ADAMTS20 | ENSP00000308165 | ENSP00000374071 | CD36 molecule (thrombospondin receptor) | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.610 |
FURIN | ACAN | ENSP00000268171 | ENSP00000387356 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region | 0.472 |
FURIN | ADAMTS20 | ENSP00000268171 | ENSP00000374071 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.561 |
KCTD9 | ADAMTS20 | ENSP00000221200 | ENSP00000374071 | potassium channel tetramerisation domain containing 9 | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.416 |
OCA2 | ADAMTS20 | ENSP00000346659 | ENSP00000374071 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.403 |
OCA2 | SLC24A5 | ENSP00000346659 | ENSP00000341550 | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | 0.877 |
SLC24A5 | ADAMTS20 | ENSP00000341550 | ENSP00000374071 | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.487 |
SLC24A5 | OCA2 | ENSP00000341550 | ENSP00000346659 | solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) | oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color | 0.877 |
TSR3 | ADAMTS20 | ENSP00000007390 | ENSP00000374071 | TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity) | ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions | 0.475 |