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STRINGSTRING
ACAN ACAN CD36 CD36 FURIN FURIN KCTD9 KCTD9 VCAN VCAN ADAMTS20 ADAMTS20 SLC24A5 SLC24A5 TSR3 TSR3 OCA2 OCA2
"ADAMTS20" - ADAM metallopeptidase with thrombospondin type 1 motif, 20 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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Score
ADAMTS20ADAM metallopeptidase with thrombospondin type 1 motif, 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions (1910 aa)    
Predicted Functional Partners:
CD36
CD36 molecule (thrombospondin receptor) (472 aa)
            score_image   0.610
FURIN
furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif (794 aa)
            score_image   0.561
SLC24A5
solute carrier family 24, member 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (500 aa)
            score_image   0.487
TSR3
TSR3, 20S rRNA accumulation, homolog (S. cerevisiae); Probable pre-rRNA processing protein involved in ribosome biogenesis (By similarity) (312 aa)
            score_image   0.475
VCAN
versican; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid (3396 aa)
            score_image   0.454
KCTD9
potassium channel tetramerisation domain containing 9 (389 aa)
            score_image   0.416
ACAN
aggrecan; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region (2530 aa)
            score_image   0.407
OCA2
oculocutaneous albinism II; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color (838 aa)
            score_image   0.403
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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