node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASH2L | MLL5 | ENSP00000340896 | ENSP00000257745 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | 0.762 |
ASH2L | SETD1A | ENSP00000340896 | ENSP00000262519 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | SET domain containing 1A; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression | 0.999 |
ASH2L | SETD1B | ENSP00000340896 | ENSP00000267197 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | SET domain containing 1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro | 0.999 |
ASH2L | SMYD1 | ENSP00000340896 | ENSP00000393453 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | SET and MYND domain containing 1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis | 0.536 |
ASH2L | SMYD4 | ENSP00000340896 | ENSP00000304360 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | SET and MYND domain containing 4 | 0.617 |
ASH2L | SMYD5 | ENSP00000340896 | ENSP00000374152 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | SMYD family member 5 | 0.512 |
ASH2L | UBC | ENSP00000340896 | ENSP00000344818 | ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis | ubiquitin C | 0.638 |
BRD1 | BRPF3 | ENSP00000216267 | ENSP00000350267 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.946 |
BRD1 | MLL5 | ENSP00000216267 | ENSP00000257745 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | 0.535 |
BRD1 | SETD1A | ENSP00000216267 | ENSP00000262519 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET domain containing 1A; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression | 0.569 |
BRD1 | SETD1B | ENSP00000216267 | ENSP00000267197 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET domain containing 1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro | 0.569 |
BRD1 | SMYD1 | ENSP00000216267 | ENSP00000393453 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET and MYND domain containing 1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis | 0.575 |
BRD1 | SMYD4 | ENSP00000216267 | ENSP00000304360 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET and MYND domain containing 4 | 0.535 |
BRD1 | SMYD5 | ENSP00000216267 | ENSP00000374152 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SMYD family member 5 | 0.535 |
BRD1 | UBC | ENSP00000216267 | ENSP00000344818 | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | ubiquitin C | 0.513 |
BRPF3 | BRD1 | ENSP00000350267 | ENSP00000216267 | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | bromodomain containing 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | 0.946 |
BRPF3 | MLL5 | ENSP00000350267 | ENSP00000257745 | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) | 0.535 |
BRPF3 | SETD1A | ENSP00000350267 | ENSP00000262519 | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET domain containing 1A; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression | 0.569 |
BRPF3 | SETD1B | ENSP00000350267 | ENSP00000267197 | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET domain containing 1B; Histone methyltransferase that specifically methylates ’Lys-4’ of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring ’Lys- 9’ residue is already methylated. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates ’Lys-4’ of histone H3 in vitro | 0.569 |
BRPF3 | SMYD1 | ENSP00000350267 | ENSP00000393453 | bromodomain and PHD finger containing, 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity | SET and MYND domain containing 1; Methylates histone H3 at ’Lys-4’ (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis | 0.535 |