Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CAMSAP1 | calmodulin regulated spectrin-associated protein 1 (1602 aa) | ||||||||||||
Predicted Functional Partners:
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 | FAM120A | family with sequence similarity 120A (1118 aa) |
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0.623 | ||||||||||
 | RNF220 | ring finger protein 220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity) (566 aa) |
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0.622 | ||||||||||
 | SPTBN1 | spectrin, beta, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane (2364 aa) |
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0.608 | |||||||||
 | RTN4RL1 | reticulon 4 receptor-like 1; May play a role in regulating axonal regeneration and plasticity in the adult central nervous system (441 aa) |
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0.574 | ||||||||||
 | ZKSCAN1 | zinc finger with KRAB and SCAN domains 1; May be involved in transcriptional regulation (563 aa) |
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0.563 | ||||||||||
 | FKBP1B | FK506 binding protein 1B, 12.6 kDa; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (108 aa) |
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0.536 | ||||||||||
 | GREM2 | gremlin 2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells (By similarity) (168 aa) |
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0.530 | ||||||||||
 | ZMYND19 | zinc finger, MYND-type containing 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling (227 aa) |
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0.518 | ||||||||||
 | TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 (1990 aa) |
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0.506 | ||||||||||
 | CALN1 | calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning (261 aa) |
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0.447 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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