Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | ESYT3 | extended synaptotagmin-like protein 3; May play a role as calcium-regulated intrinsic membrane protein (By similarity) (886 aa) | ||||||||||||
Predicted Functional Partners:
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 | TNF | tumor necrosis factor (233 aa) |
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0.615 | ||||||||||
 | ESYT1 | extended synaptotagmin-like protein 1; May play a role as calcium-regulated intrinsic membrane protein (By similarity) (1114 aa) |
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0.611 | ||||||||
 | ESYT2 | extended synaptotagmin-like protein 2 (893 aa) |
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0.601 | ||||||||
 | MYC | v-myc myelocytomatosis viral oncogene homolog (avian); Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5’-CAC[GA]TG-3’. Seems to activate the transcription of growth-related genes (454 aa) |
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0.591 | ||||||||||
 | SOX14 | SRY (sex determining region Y)-box 14; Acts as a negative regulator of transcription (By similarity) (240 aa) |
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0.499 | ||||||||||
 | EXOC8 | exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (725 aa) |
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0.487 | ||||||||||
 | EXOC1 | exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (894 aa) |
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0.487 | ||||||||||
 | EXOC2 | exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane (924 aa) |
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0.487 | ||||||||||
 | DZIP1L | DAZ interacting protein 1-like (767 aa) |
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0.472 | ||||||||||
 | CRYBA2 | crystallin, beta A2; Crystallins are the dominant structural components of the vertebrate eye lens (197 aa) |
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0.471 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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