ARNTL protein (Homo sapiens) - STRING network view

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ARNTL

aryl hydrocarbon receptor nuclear translocator-like (625 aa)

Predicted Functional Partners:

CLOCK

0.999

CRY1

0.999

CRY2

0.999

CSNK1E

0.999

NPAS2

0.998

PER3

0.997

PER2

0.997

PER1

0.997

NR1D1

0.994

BHLHE40

0.989

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL	BHLHE40	ENSP00000374357	ENSP00000256495	aryl hydrocarbon receptor nuclear translocator-like	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	0.989
ARNTL	CLOCK	ENSP00000374357	ENSP00000308741	aryl hydrocarbon receptor nuclear translocator-like	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	0.999
ARNTL	CRY1	ENSP00000374357	ENSP00000008527	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	CRY2	ENSP00000374357	ENSP00000406751	aryl hydrocarbon receptor nuclear translocator-like	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.999
ARNTL	CSNK1E	ENSP00000374357	ENSP00000352929	aryl hydrocarbon receptor nuclear translocator-like	casein kinase 1, epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm. Inhibits cytokine-induced granuloytic differentiation	0.999
ARNTL	NPAS2	ENSP00000374357	ENSP00000338283	aryl hydrocarbon receptor nuclear translocator-like	neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)	0.998
ARNTL	NR1D1	ENSP00000374357	ENSP00000246672	aryl hydrocarbon receptor nuclear translocator-like	nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine	0.994
ARNTL	PER1	ENSP00000374357	ENSP00000314420	aryl hydrocarbon receptor nuclear translocator-like	period homolog 1 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation. Can bind heme (By similarity)	0.997
ARNTL	PER2	ENSP00000374357	ENSP00000254657	aryl hydrocarbon receptor nuclear translocator-like	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.997
ARNTL	PER3	ENSP00000374357	ENSP00000355031	aryl hydrocarbon receptor nuclear translocator-like	period homolog 3 (Drosophila)	0.997
BHLHE40	ARNTL	ENSP00000256495	ENSP00000374357	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	aryl hydrocarbon receptor nuclear translocator-like	0.989
BHLHE40	CLOCK	ENSP00000256495	ENSP00000308741	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	0.958
BHLHE40	CRY1	ENSP00000256495	ENSP00000008527	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	cryptochrome 1 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.789
BHLHE40	CRY2	ENSP00000256495	ENSP00000406751	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	cryptochrome 2 (photolyase-like); Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK\|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK\|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL	0.598
BHLHE40	NPAS2	ENSP00000256495	ENSP00000338283	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	neuronal PAS domain protein 2; BMAL1-NPAS2 heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)	0.988
BHLHE40	NR1D1	ENSP00000256495	ENSP00000246672	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	nuclear receptor subfamily 1, group D, member 1; Functions as a constitutive transcriptional repressor. In collaboration with SP1, activates GJA1 transcription (By similarity). Possible receptor for triiodothyronine	0.760
BHLHE40	PER2	ENSP00000256495	ENSP00000254657	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	period homolog 2 (Drosophila); Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK\|NPAS2-BMAL1\|BMAL2-induced transactivation (By similarity)	0.788
BHLHE40	PER3	ENSP00000256495	ENSP00000355031	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	period homolog 3 (Drosophila)	0.792
CLOCK	ARNTL	ENSP00000308741	ENSP00000374357	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	aryl hydrocarbon receptor nuclear translocator-like	0.999
CLOCK	BHLHE40	ENSP00000308741	ENSP00000256495	clock homolog (mouse); ARNTL/2-CLOCK heterodimers activate E-box element (5’- CACGTG-3’) transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate- ARNTL (By similarity). Plays a role i [...]	basic helix-loop-helix family, member e40; May function as a transcriptional factor to modulate chondrogenesis in response to the cAMP pathway	0.958

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