FAM168B protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

FAM168B

family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) (195 aa)

Predicted Functional Partners:

FAM123C

0.659

DENND6A

0.520

ZNF280B

0.496

DNAJB14

0.450

FAM160B1

0.423

DDI1

0.409

UBE2NL

0.408

ANKRD13C

0.407

SLC10A7

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD13C	FAM168B	ENSP00000359982	ENSP00000374565	ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.407
ANKRD13C	SLC10A7	ENSP00000359982	ENSP00000334594	ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER	solute carrier family 10 (sodium/bile acid cotransporter family), member 7	0.414
ANKRD13C	UBE2NL	ENSP00000359982	ENSP00000359525	ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER	ubiquitin-conjugating enzyme E2N-like	0.416
DDI1	DENND6A	ENSP00000302805	ENSP00000311401	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	0.414
DDI1	FAM168B	ENSP00000302805	ENSP00000374565	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.409
DDI1	ZNF280B	ENSP00000302805	ENSP00000353586	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	zinc finger protein 280B; May function as a transcription factor	0.467
DENND6A	DDI1	ENSP00000311401	ENSP00000302805	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	0.414
DENND6A	DNAJB14	ENSP00000311401	ENSP00000404381	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity)	0.461
DENND6A	FAM160B1	ENSP00000311401	ENSP00000358251	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	family with sequence similarity 160, member B1	0.435
DENND6A	FAM168B	ENSP00000311401	ENSP00000374565	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.520
DENND6A	ZNF280B	ENSP00000311401	ENSP00000353586	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	zinc finger protein 280B; May function as a transcription factor	0.412
DNAJB14	DENND6A	ENSP00000404381	ENSP00000311401	DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity)	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	0.461
DNAJB14	FAM168B	ENSP00000404381	ENSP00000374565	DnaJ (Hsp40) homolog, subfamily B, member 14; May act as a co-chaperone (By similarity)	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.450
FAM123C	FAM168B	ENSP00000314914	ENSP00000374565	family with sequence similarity 123C; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity)	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.659
FAM160B1	DENND6A	ENSP00000358251	ENSP00000311401	family with sequence similarity 160, member B1	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	0.435
FAM160B1	FAM168B	ENSP00000358251	ENSP00000374565	family with sequence similarity 160, member B1	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	0.423
FAM160B1	ZNF280B	ENSP00000358251	ENSP00000353586	family with sequence similarity 160, member B1	zinc finger protein 280B; May function as a transcription factor	0.464
FAM168B	ANKRD13C	ENSP00000374565	ENSP00000359982	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	ankyrin repeat domain 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER	0.407
FAM168B	DDI1	ENSP00000374565	ENSP00000302805	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	0.409
FAM168B	DENND6A	ENSP00000374565	ENSP00000311401	family with sequence similarity 168, member B; Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity)	DENN/MADD domain containing 6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes	0.520

page 1 of 2

Textmining

Cooccurrence

Coexpression

Neighborhood

Experiments

Fusion

Databases

© STRING Consortium 2017

Credits

Access

Info

About