node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDKRB2 | CNR1 | ENSP00000307713 | ENSP00000358511 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | cannabinoid receptor 1 (brain) | 0.907 |
BDKRB2 | DRD3 | ENSP00000307713 | ENSP00000373169 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation | 0.901 |
BDKRB2 | GRM2 | ENSP00000307713 | ENSP00000378492 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | glutamate receptor, metabotropic 2; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization | 0.900 |
BDKRB2 | GRM3 | ENSP00000307713 | ENSP00000355316 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.900 |
BDKRB2 | GRM6 | ENSP00000307713 | ENSP00000231188 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | glutamate receptor, metabotropic 6; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.901 |
BDKRB2 | GRM8 | ENSP00000307713 | ENSP00000344173 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | glutamate receptor, metabotropic 8 | 0.900 |
BDKRB2 | HCAR2 | ENSP00000307713 | ENSP00000375066 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and p [...] | 0.918 |
BDKRB2 | OXGR1 | ENSP00000307713 | ENSP00000298440 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
BDKRB2 | PTGER3 | ENSP00000307713 | ENSP00000349003 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.905 |
BDKRB2 | SUCNR1 | ENSP00000307713 | ENSP00000355156 | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | succinate receptor 1; Receptor for succinate | 0.900 |
CNR1 | BDKRB2 | ENSP00000358511 | ENSP00000307713 | cannabinoid receptor 1 (brain) | bradykinin receptor B2; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system | 0.907 |
CNR1 | DRD3 | ENSP00000358511 | ENSP00000373169 | cannabinoid receptor 1 (brain) | dopamine receptor D3; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation | 0.925 |
CNR1 | GRM2 | ENSP00000358511 | ENSP00000378492 | cannabinoid receptor 1 (brain) | glutamate receptor, metabotropic 2; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization | 0.950 |
CNR1 | GRM3 | ENSP00000358511 | ENSP00000355316 | cannabinoid receptor 1 (brain) | glutamate receptor, metabotropic 3; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.927 |
CNR1 | GRM6 | ENSP00000358511 | ENSP00000231188 | cannabinoid receptor 1 (brain) | glutamate receptor, metabotropic 6; Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity | 0.920 |
CNR1 | GRM8 | ENSP00000358511 | ENSP00000344173 | cannabinoid receptor 1 (brain) | glutamate receptor, metabotropic 8 | 0.925 |
CNR1 | HCAR2 | ENSP00000358511 | ENSP00000375066 | cannabinoid receptor 1 (brain) | hydroxycarboxylic acid receptor 2; Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and p [...] | 0.912 |
CNR1 | OXGR1 | ENSP00000358511 | ENSP00000298440 | cannabinoid receptor 1 (brain) | oxoglutarate (alpha-ketoglutarate) receptor 1; Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity) | 0.900 |
CNR1 | PTGER3 | ENSP00000358511 | ENSP00000349003 | cannabinoid receptor 1 (brain) | prostaglandin E receptor 3 (subtype EP3); Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second me [...] | 0.927 |
CNR1 | SUCNR1 | ENSP00000358511 | ENSP00000355156 | cannabinoid receptor 1 (brain) | succinate receptor 1; Receptor for succinate | 0.900 |