| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALKBH5 | BCAS3 | ENSP00000382091 | ENSP00000375067 | alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis | breast carcinoma amplified sequence 3 | 0.582 |
| APPBP2 | BCAS3 | ENSP00000083182 | ENSP00000375067 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | breast carcinoma amplified sequence 3 | 0.738 |
| BCAS3 | ALKBH5 | ENSP00000375067 | ENSP00000382091 | breast carcinoma amplified sequence 3 | alkB, alkylation repair homolog 5 (E. coli); Dioxygenase that demethylates RNA by oxidative demethylation- specifically demethylates N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Requires molecular oxygen, alpha- ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA processing and export and is required for spermatogenesis | 0.582 |
| BCAS3 | APPBP2 | ENSP00000375067 | ENSP00000083182 | breast carcinoma amplified sequence 3 | amyloid beta precursor protein (cytoplasmic tail) binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface | 0.738 |
| BCAS3 | BCAS4 | ENSP00000375067 | ENSP00000351642 | breast carcinoma amplified sequence 3 | breast carcinoma amplified sequence 4 | 0.867 |
| BCAS3 | C16orf70 | ENSP00000375067 | ENSP00000219139 | breast carcinoma amplified sequence 3 | chromosome 16 open reading frame 70 | 0.667 |
| BCAS3 | C17orf82 | ENSP00000375067 | ENSP00000335229 | breast carcinoma amplified sequence 3 | chromosome 17 open reading frame 82 | 0.750 |
| BCAS3 | ESR1 | ENSP00000375067 | ENSP00000206249 | breast carcinoma amplified sequence 3 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | 0.865 |
| BCAS3 | KAT2B | ENSP00000375067 | ENSP00000263754 | breast carcinoma amplified sequence 3 | K(lysine) acetyltransferase 2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes | 0.805 |
| BCAS3 | MTA1 | ENSP00000375067 | ENSP00000333633 | breast carcinoma amplified sequence 3 | metastasis associated 1; May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER | 0.620 |
| BCAS3 | MTA3 | ENSP00000375067 | ENSP00000385045 | breast carcinoma amplified sequence 3 | metastasis associated 1 family, member 3; Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels | 0.920 |
| BCAS3 | TFF1 | ENSP00000375067 | ENSP00000291527 | breast carcinoma amplified sequence 3 | trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine | 0.811 |
| BCAS4 | BCAS3 | ENSP00000351642 | ENSP00000375067 | breast carcinoma amplified sequence 4 | breast carcinoma amplified sequence 3 | 0.867 |
| C16orf70 | BCAS3 | ENSP00000219139 | ENSP00000375067 | chromosome 16 open reading frame 70 | breast carcinoma amplified sequence 3 | 0.667 |
| C17orf82 | BCAS3 | ENSP00000335229 | ENSP00000375067 | chromosome 17 open reading frame 82 | breast carcinoma amplified sequence 3 | 0.750 |
| ESR1 | BCAS3 | ENSP00000206249 | ENSP00000375067 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | breast carcinoma amplified sequence 3 | 0.865 |
| ESR1 | KAT2B | ENSP00000206249 | ENSP00000263754 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | K(lysine) acetyltransferase 2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat’s transactivating activity and may help inducing chromatin remodeling of proviral genes | 0.650 |
| ESR1 | MTA1 | ENSP00000206249 | ENSP00000333633 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | metastasis associated 1; May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER | 0.999 |
| ESR1 | MTA3 | ENSP00000206249 | ENSP00000385045 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | metastasis associated 1 family, member 3; Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels | 0.978 |
| ESR1 | TFF1 | ENSP00000206249 | ENSP00000291527 | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine | 0.999 |
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