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STRINGSTRING
FURIN FURIN COL23A1 COL23A1 COL4A5 COL4A5 COL25A1 COL25A1 COL13A1 COL13A1 COL15A1 COL15A1 COL9A2 COL9A2 COL8A1 COL8A1 COL12A1 COL12A1 COL20A1 COL20A1 COL27A1 COL27A1
"COL23A1" - collagen, type XXIII, alpha 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
COL23A1collagen, type XXIII, alpha 1 (540 aa)    
Predicted Functional Partners:
FURIN
furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif (794 aa)
        score_image score_image score_image   0.981
COL13A1
collagen, type XIII, alpha 1 (717 aa)
          score_image score_image score_image 0.931
COL25A1
collagen, type XXV, alpha 1; Inhibits fibrillization of beta amyloid peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (654 aa)
    score_image     score_image score_image score_image 0.927
COL9A2
collagen, type IX, alpha 2; Structural component of hyaline cartilage and vitreous of the eye (689 aa)
    score_image     score_image score_image score_image 0.919
COL20A1
collagen, type XX, alpha 1; Probable collagen protein (1284 aa)
          score_image score_image score_image 0.916
COL8A1
collagen, type VIII, alpha 1; Macromolecular component of the subendothelium. Major component of the Descemet’s membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (744 aa)
          score_image score_image   0.913
COL15A1
collagen, type XV, alpha 1; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle (1388 aa)
          score_image score_image score_image 0.911
COL4A5
collagen, type IV, alpha 5; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a ’chicken-wire’ meshwork together with laminins, proteoglycans and entactin/nidogen (1691 aa)
          score_image score_image score_image 0.911
COL12A1
collagen, type XII, alpha 1; Type XII collagen interacts with type I collagen- containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix (By similarity) (3063 aa)
          score_image score_image score_image 0.910
COL27A1
collagen, type XXVII, alpha 1; Plays a role during the calcification of cartilage and the transition of cartilage to bone (1860 aa)
          score_image score_image score_image 0.909
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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