node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG4C | ZNF628 | ENSP00000322159 | ENSP00000375598 | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.536 |
CAPN13 | PTPN23 | ENSP00000295055 | ENSP00000265562 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.699 |
CAPN13 | ZNF628 | ENSP00000295055 | ENSP00000375598 | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.430 |
DNAJC5 | ZNF628 | ENSP00000354111 | ENSP00000375598 | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.478 |
FBXL19 | ZNF628 | ENSP00000369666 | ENSP00000375598 | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.501 |
KDM2A | ZNF628 | ENSP00000432786 | ENSP00000375598 | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.501 |
KDM2B | ZNF628 | ENSP00000366271 | ENSP00000375598 | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.501 |
PASK | ZNF628 | ENSP00000234040 | ENSP00000375598 | PAS domain containing serine/threonine kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha c [...] | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.547 |
PTPN23 | CAPN13 | ENSP00000265562 | ENSP00000295055 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.699 |
PTPN23 | ZNF628 | ENSP00000265562 | ENSP00000375598 | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.476 |
RANBP2 | ZNF628 | ENSP00000283195 | ENSP00000375598 | RAN binding protein 2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at ’Lys-490’ which is essential for the proper assembly of PML-NB | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.465 |
XRN1 | ZNF628 | ENSP00000264951 | ENSP00000375598 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | 0.543 |
ZNF628 | ATG4C | ENSP00000375598 | ENSP00000322159 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | autophagy related 4C, cysteine peptidase; Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes | 0.536 |
ZNF628 | CAPN13 | ENSP00000375598 | ENSP00000295055 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | calpain 13; Probable non-lysosomal thiol-protease (By similarity) | 0.430 |
ZNF628 | DNAJC5 | ENSP00000375598 | ENSP00000354111 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | DnaJ (Hsp40) homolog, subfamily C, member 5; May have an important role in presynaptic function. May be involved in calcium-dependent neurotransmitter release at nerve endings (By similarity) | 0.478 |
ZNF628 | FBXL19 | ENSP00000375598 | ENSP00000369666 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.501 |
ZNF628 | KDM2A | ENSP00000375598 | ENSP00000432786 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...] | 0.501 |
ZNF628 | KDM2B | ENSP00000375598 | ENSP00000366271 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...] | 0.501 |
ZNF628 | PASK | ENSP00000375598 | ENSP00000234040 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | PAS domain containing serine/threonine kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis- regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha c [...] | 0.547 |
ZNF628 | PTPN23 | ENSP00000375598 | ENSP00000265562 | zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5’-TTGGTT-3’ (By similarity) | protein tyrosine phosphatase, non-receptor type 23; May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis | 0.476 |