node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCT2 | MOB4 | ENSP00000299300 | ENSP00000315702 | chaperonin containing TCP1, subunit 2 (beta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | 0.999 |
CCT2 | PPP2CA | ENSP00000299300 | ENSP00000418447 | chaperonin containing TCP1, subunit 2 (beta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | 0.999 |
CCT2 | STRN4 | ENSP00000299300 | ENSP00000375777 | chaperonin containing TCP1, subunit 2 (beta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
CTTNBP2NL | MOB4 | ENSP00000271277 | ENSP00000315702 | CTTNBP2 N-terminal like | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | 0.999 |
CTTNBP2NL | MST4 | ENSP00000271277 | ENSP00000377867 | CTTNBP2 N-terminal like | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | 0.999 |
CTTNBP2NL | PDCD10 | ENSP00000271277 | ENSP00000376506 | CTTNBP2 N-terminal like | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.999 |
CTTNBP2NL | PPP2CA | ENSP00000271277 | ENSP00000418447 | CTTNBP2 N-terminal like | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | 0.999 |
CTTNBP2NL | PPP2R1A | ENSP00000271277 | ENSP00000324804 | CTTNBP2 N-terminal like | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.999 |
CTTNBP2NL | PPP2R1B | ENSP00000271277 | ENSP00000311344 | CTTNBP2 N-terminal like | protein phosphatase 2, regulatory subunit A, beta; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit | 0.999 |
CTTNBP2NL | SIKE1 | ENSP00000271277 | ENSP00000358541 | CTTNBP2 N-terminal like | suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways | 0.584 |
CTTNBP2NL | STRIP1 | ENSP00000271277 | ENSP00000358810 | CTTNBP2 N-terminal like | striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape | 0.999 |
CTTNBP2NL | STRN4 | ENSP00000271277 | ENSP00000375777 | CTTNBP2 N-terminal like | striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein | 0.999 |
MOB4 | CCT2 | ENSP00000315702 | ENSP00000299300 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | chaperonin containing TCP1, subunit 2 (beta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | 0.999 |
MOB4 | CTTNBP2NL | ENSP00000315702 | ENSP00000271277 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | CTTNBP2 N-terminal like | 0.999 |
MOB4 | MST4 | ENSP00000315702 | ENSP00000377867 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | Serine/threonine-protein kinase MST4 ; Mediator of cell growth. Modulates apoptosis | 0.999 |
MOB4 | PDCD10 | ENSP00000315702 | ENSP00000376506 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) | 0.999 |
MOB4 | PPP2CA | ENSP00000315702 | ENSP00000418447 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ | 0.999 |
MOB4 | PPP2R1A | ENSP00000315702 | ENSP00000324804 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | protein phosphatase 2, regulatory subunit A, alpha; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Required for proper chromosome segregation and for centromeric localization of SGOL1 in mitosis | 0.999 |
MOB4 | PPP2R1B | ENSP00000315702 | ENSP00000311344 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | protein phosphatase 2, regulatory subunit A, beta; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit | 0.999 |
MOB4 | SIKE1 | ENSP00000315702 | ENSP00000358541 | MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) | suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways | 0.999 |